Document Detail


Surveillance of Chagas disease among at-risk blood donors in Italy: preliminary results from Umberto I Polyclinic in Rome.
MedLine Citation:
PMID:  24120609     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Chagas disease is a parasitic disease due to Trypanosoma cruzi, endemic in Central and Southern America, where the protozoon infects about 8-10 million people. In rural areas the infection is acquired mostly through reduviidae insect vectors, whereas in urban ones it is acquired mainly through the transfusion of blood products, vertical transmission and organ transplantation. The important migratory flows of the last decades have focused attention on possible T. cruzi transmission by transfusion also in non-endemic countries, and platelets have been recognised as the main origin of infection for recipients from serologically-positive Latino-American donors.
MATERIALS AND METHODS: In order to avoid the occurrence of transfusion-related cases, in 2010 systematic screening for anti-T. cruzi antibodies was started at the Umberto I Polyclinic in Rome, controlling blood donors born and/or coming from Latin-American countries in which the disease is endemic. The aim of this paper is to report the preliminary results achieved since the introduction of this screening.
RESULTS: Anti-T. cruzi antibodies have been detected to date in 3.9% out of the 128 people examined. A seropositive subject also proved positive by polymerase chain reaction analysis and showed very light parasitaemia.
DISCUSSION: The preliminary results are quite alarming. Indeed, serological findings exceed those reported in other non-endemic countries, and Italian travellers proved to be an insidious possible source of direct transmission. The need for systematic screening of at-risk blood donors also in non-endemic countries is emphasised.
Authors:
Simona Gabrielli; Gabriella Girelli; Francesco Vaia; Mariella Santonicola; Azis Fakeri; Gabriella Cancrini
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-10-02
Journal Detail:
Title:  Blood transfusion = Trasfusione del sangue     Volume:  -     ISSN:  1723-2007     ISO Abbreviation:  Blood Transfus     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-10-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101237479     Medline TA:  Blood Transfus     Country:  -    
Other Details:
Languages:  ENG     Pagination:  558-562     Citation Subset:  -    
Affiliation:
Parasitological Analyses Unit Department of Public Health and Infectious Diseases, "Sapienza" University, Rome, Italy.
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