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Surrogacy as a good option for treatment of repeated implantation failure: a case series.
MedLine Citation:
PMID:  24639697     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Repeated implantation failure (RIF) is defined as pregnancy failure after two to six times with at least ten high grade embryo transfer to uterus. A variety of causes have been anticipated for RIF, including anatomical, autoimmune, genetics, endocrine and thrombotic anomalies. Factors responsible for RIF have important implication regarding treatment however in many couples a perfect cause cannot be found.
CASES: In these case series, we reported nine couples with RIF that after investigation no definitive etiology was found for RIF and empirical therapy by heparin, aspirin and or immunotherapy was not effective. In these cases we recommended transfer of embryos to surrogate uterus. Nine patients were studied and six of them developed a normal pregnancy (pregnancy rate=66.66%).
CONCLUSION: This study showed that surrogacy is a good option for treatment of RIF.
Authors:
Nastaran Aflatoonian; Maryam Eftekhar; Behrooz Aflatoonian; Elham Rahmani; Abass Aflatoonian
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Iranian journal of reproductive medicine     Volume:  11     ISSN:  1680-6433     ISO Abbreviation:  Iran J Reprod Med     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2014-03-18     Completed Date:  2014-03-18     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  101463749     Medline TA:  Iran J Reprod Med     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  77-80     Citation Subset:  -    
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