Document Detail

Surgically-induced inflammation with 20-, 23-, and 25-gauge vitrectomy systems: an experimental study.
MedLine Citation:
PMID:  19262433     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate postoperative intraocular inflammation induced in rabbit eyes subjected to surgery using different vitrectomy systems. METHODS: The 20-, 23-, and 25-gauge vitrectomy were performed on a total of 12 rabbit eyes, divided into 3 respective groups, and 4 rabbit eyes were used as a normal control group. The surgery consisted of posterior vitreous detachment induction and core vitrectomy. The main outcome measures were operative time, volume of balanced saline solution consumed and the intravitreal total protein concentration, determined by bicinchoninic acid protein assays, obtained by vitreous tap on postoperative days 1, 3, and 7. RESULTS: The intravitreal protein averages in the 20-, 23-, and 25-gauge vitrectomy groups were, respectively, 31 +/- 4.1, 21 +/- 2.3, and 7 +/- 3.4 mg/mL on postoperative Day 1 (0.13 +/- 0.02 mg/mL in the control eye). The intravitreal protein concentration level was significantly lower with the 25-gauge than with 20- or 23-gauge vitrectomy (P < 0.001), and there were no significant differences in intravitreal protein between the 20- and 23-gauge system on postoperative days 1 and 3. At 7 days postoperatively, there were no significant differences in the intravitreal protein levels among the three groups. Significantly less balanced saline solution was consumed in the 25-gauge vitrectomy group (P < 0.001). CONCLUSION: Postoperative intraocular inflammation can vary among vitrectomy systems. A smaller gauge can minimize the inflammation associated with vitrectomy.
Yuji Inoue; Kazuaki Kadonosono; Tadashi Yamakawa; Eiichi Uchio; Yoichiro Watanabe; Yasuo Yanagi; Yasuhiro Tamaki; Makoto Araie
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Retina (Philadelphia, Pa.)     Volume:  29     ISSN:  1539-2864     ISO Abbreviation:  Retina (Philadelphia, Pa.)     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-14     Completed Date:  2009-05-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309919     Medline TA:  Retina     Country:  United States    
Other Details:
Languages:  eng     Pagination:  477-80     Citation Subset:  IM    
Department of Ophthalmology, School of Medicine, University of Tokyo, Tokyo, Japan.
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MeSH Terms
Endophthalmitis / etiology*,  metabolism
Equipment Design
Eye Proteins / metabolism
Osmolar Concentration
Postoperative Period
Sodium Chloride / administration & dosage
Time Factors
Vitrectomy / adverse effects*,  instrumentation*,  methods
Vitreous Body / metabolism
Reg. No./Substance:
0/Eye Proteins; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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