| Surgically correctable hypertension caused by primary aldosteronism. | |
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MedLine Citation:
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PMID: 16980201 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Surgically correctable forms of primary aldosteronism are generally held to be less common than forms requiring medical therapy. However, with the availability of improved diagnostic techniques and the adoption of a systematic and thorough diagnostic work-up they can be identified more commonly than expected. Adrenal vein sampling (AVS) for measurement of cortisol and aldosterone has emerged as the 'gold standard' diagnostic test for identifying unilateral causes of primary aldosteronism that are amenable to surgical cure. Adrenalectomy can provide long-term normalisation of blood pressure and correction of primary aldosteronism in about 55% of patients with an aldosterone-producing adenoma and can markedly ameliorate blood pressure control in the rest. This chapter summarises the diagnostic work-up suggested for identifying these forms and examines the other diseases mimicking mineralocorticoid excess that enter into the differential diagnosis of surgically curable primary aldosteronism. |
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Authors:
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Gian Paolo Rossi |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Best practice & research. Clinical endocrinology & metabolism Volume: 20 ISSN: 1521-690X ISO Abbreviation: Best Pract. Res. Clin. Endocrinol. Metab. Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-09-18 Completed Date: 2006-12-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101120682 Medline TA: Best Pract Res Clin Endocrinol Metab Country: England |
Other Details:
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Languages: eng Pagination: 385-400 Citation Subset: IM |
Affiliation:
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Department of Clinical & Experimental Medicine, Clinica Medica 4, University Hospital, University of Padova, Via Giustiniani 2, 35126 Padova, Italy. gianpaolo.rossi@unipd.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Gland Neoplasms
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complications,
surgery Adrenal Glands / blood supply, radionuclide imaging Adrenalectomy Adrenocortical Adenoma / complications, surgery Aldosterone / adverse effects, secretion Algorithms Diagnosis, Differential Humans Hyperaldosteronism / classification, complications*, diagnosis Hypertension / etiology*, surgery* Paraneoplastic Endocrine Syndromes / diagnosis |
| Chemical | |
Reg. No./Substance:
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52-39-1/Aldosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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