Document Detail

Surgical ventricular restoration and other surgical approaches to heart failure.
MedLine Citation:
PMID:  16036021     Owner:  NLM     Status:  MEDLINE    
Historically, few patients with ischemic congestive heart failure (CHF) have been considered for cardiac surgical intervention unless there was an obvious need for coronary revascularization or valve repair. New surgical procedures and non-mechanical assist devices are being used and tested in patients with end-stage CHF. We report on The Ohio State University Medical Center's early involvement in the international and multi-institutional Surgical Treatment for Ischemic Heart Failure (STICH) trial, which is evaluating the value of coronary artery bypass in patients with ischemic CHF as compared to medical therapies alone, and whether surgical ventricular restoration (SVR) offers additional benefit to patients with dilated hearts undergoing revascularization. Beyond standard coronary revascularization and SVR, new surgically deployed devices that attempt to augment ventricular performance by direct restraint of left ventricular dilatation or by reducing ventricular wall stress through altering ventricular shape are reviewed. The growing clinical and experimental experience with cellular cardiomyoplasty (in particular, autologous skeletal myoblast and adult-derived stem transplantation) also is reviewed. This review is intended to express the institutional insights of the authors, who have been involved in clinical trials and basic science research in each of these areas.
Patrick I McConnell; Robert E Michler
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current heart failure reports     Volume:  1     ISSN:  1546-9530     ISO Abbreviation:  Curr Heart Fail Rep     Publication Date:    2004 Apr-May
Date Detail:
Created Date:  2005-07-22     Completed Date:  2005-09-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101196487     Medline TA:  Curr Heart Fail Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  21-9     Citation Subset:  IM    
Division of Cardiothoracic Surgery, N847 Doan Hall, 410 W. 10th Avenue, Columbus, OH 43210, USA.
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MeSH Terms
Clinical Trials as Topic
Coronary Artery Bypass
Heart Failure / surgery*
Heart Ventricles / surgery*
Heart-Assist Devices
Myoblasts, Cardiac / transplantation
Myoblasts, Skeletal / transplantation
Stem Cell Transplantation

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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