| Surgical treatment for rabbits' femoral arteries subjected to gunshot wounds combining with seawater immersion. | |
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MedLine Citation:
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PMID: 16176764 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the surgical treatment methods and evaluate the outcome of gunshot wounds combining with seawater immersion in rabbits' femoral arteries. METHODS: One hundred healthy New Zealand white rabbits (either sex, 3.14 kg+/-0.61 kg in weight) were randomly divided into a seawater immersion group (n=50) and a simple injury group (n=50). The unilateral femoral arteries of all the rabbits were injured by 0.38 g steel spheres with velocity of 600-800 m/s fired by a 7.62 mm rifle. The rabbits in the seawater immersion group were immersed in seawater (saline content of 2.54%, pH 8.2-8.4, and at 21 degrees C) for 60 minutes but those in the simple injury group were not. After the injured segment (observed by naked eyes) of the femoral artery was excised, the blood flow restoration was reconstructed by direct end-to-end anastomosis, reversed autogenous venous grafting or cryopreserved arterial allografting, according to the length of the arterial defects. At 24 hours, and 7, 14 and 21 days after operation, the blood flow was examined. Operative exploration was performed for the animals with partly or fully obstructed blood flow. The tissues around the anastomosis sites and the grafts were harvested for pathological observation under a light microscope and an electron microscope. RESULTS: In the rabbits with completely transected injury, the unobstructed rates in the first 3 weeks after operation were 80.00% in the seawater immersion group and 86.67% in the single injury group, and no significant difference was found between the two groups (P>0.1). In the rabbits with arterial contusion injury, the unobstructed rates in the first 3 weeks after operation were 86.67% in the seawater immersion group and 82.35% in the single injury group, and no significant difference was found between the two groups (P>0.1). Most thrombosis occurred in the first operative week. Atypical endothelial cells were detected at the anastomosis sites at the first operative week, and the anastomosis sites were lined with endothelial cells in 3 weeks postoperatively. CONCLUSIONS: During the surgical treatment for gunshot wounds combining with seawater immersion, resection of the grossly-injured artery and routine artery reconstruction can obtain satisfactory outcome. Homologous artery is a kind of vascular graft with certain applied value. |
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Authors:
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Peng Liu; Xue-liang Peng; Jin-cai Liu; Xi-nan Lai; Liang-chao Zhang; Guo-ping Wu; Li-li Wang |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Chinese journal of traumatology = Zhonghua chuang shang za zhi / Chinese Medical Association Volume: 8 ISSN: 1008-1275 ISO Abbreviation: Chin. J. Traumatol. Publication Date: 2005 Oct |
Date Detail:
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Created Date: 2005-09-22 Completed Date: 2005-11-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100886162 Medline TA: Chin J Traumatol Country: China |
Other Details:
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Languages: eng Pagination: 311-6 Citation Subset: IM |
Affiliation:
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Department of Orthopaedics, Research Institute of Field Surgery & Daping Hospital, Third Military Medical University, Chongqing 400042, China. 13983013862@vip.163.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Disease Models, Animal Female Femoral Artery / injuries*, pathology, radiography, surgery* Hydrotherapy / methods* Male Rabbits Random Allocation Seawater Treatment Outcome Wound Healing Wounds, Gunshot / pathology, radiography, therapy* |
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