Document Detail


Surgical treatment of low- and intermediate-risk papillary thyroid cancer with minimally invasive video-assisted thyroidectomy.
MedLine Citation:
PMID:  19223525     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Minimally invasive video-assisted thyroidectomy (MIVAT) was introduced in the clinical practice to treat small benign thyroid nodules. This method has recently been demonstrated to produce the same completeness as a conventional thyroidectomy in patients with papillary thyroid cancer (PTC). The low number of treated cases and the limited follow-up of these patients represent the major limitations of these studies. OBJECTIVE: The aim of the study was to compare the outcome of two groups of PTC patients, one treated with MIVAT and the other with conventional thyroidectomy, after a median follow-up of 5 yr. STUDY GROUP: A total of 221 PTC patients were enrolled in this study according to the following criteria: 171 were treated with MIVAT (group A), and 50 were treated with conventional thyroidectomy (group B). RESULTS: The outcome and the cumulative (131)I activity administered to achieve curative status were compared. After a mean follow-up of 3.6 +/- 1.5 yr (range, 1-8 yr; median, 5 yr), no differences were found between group A and group B. A similar rate of permanent hypoparathyroidism and/or nerve cord palsy was found in both groups. CONCLUSION: We demonstrated that PTC patients operated on with MIVAT had a good outcome after 5 yr. This was similar to the outcome of patients treated with conventional thyroidectomy and the same degree of exposure to (131)I. These results, together with the evidence of a similar degree of completeness and rate of complications between the two surgical techniques, show that MIVAT is a valid option to treat low- and intermediate-risk PTC patients.
Authors:
Paolo Miccoli; Aldo Pinchera; Gabriele Materazzi; Agnese Biagini; Piero Berti; Pinuccia Faviana; Eleonora Molinaro; David Viola; Rossella Elisei
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-02-17
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  94     ISSN:  1945-7197     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-07     Completed Date:  2009-05-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1618-22     Citation Subset:  AIM; IM    
Affiliation:
Department of Surgery, University of Pisa, Via Roma 64, 56100 Pisa, Italy. p.miccoli@dc.med.unipi.it
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Carcinoma, Papillary / pathology,  radiotherapy,  surgery*
Child
Female
Follow-Up Studies
Humans
Hypoparathyroidism / epidemiology,  etiology
Iodine Radioisotopes / therapeutic use
Male
Middle Aged
Paralysis / epidemiology,  etiology
Postoperative Complications / epidemiology
Risk
Surgical Procedures, Minimally Invasive / adverse effects,  methods*
Thyroid Neoplasms / pathology,  radiotherapy,  surgery*
Thyroidectomy / adverse effects,  methods*
Treatment Outcome
Video-Assisted Surgery / adverse effects,  methods*
Young Adult
Chemical
Reg. No./Substance:
0/Iodine Radioisotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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