Document Detail

Surgical treatment of doxorubicin-induced heart failure.
MedLine Citation:
PMID:  20072969     Owner:  NLM     Status:  MEDLINE    
Doxorubicin-induced heart failure is a rare, but serious illness and is well-known to be difficult to treat. Prevention strategies have not demonstrated the expected success and unfortunately, this specific type of heart failure does not respond to the usual medical therapies as do other kinds of heart failure. Therefore, surgical procedures may be necessary in some patients. Cardiac transplantation is performed in most cases but this requires cure of the neoplastic disease. This usually requires a recurrence-free interval of several years which is associated with a high attrition rate in these patients due to their cardiac disease. Therefore, ventricular assist devices may be implanted in selected patients as a bridge to transplantation or destination therapy. This review focuses on the surgical options for doxorubicin-induced heart failure and discusses their efficacy as well as their clinical applicability.
S Christiansen
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-01-13
Journal Detail:
Title:  The Thoracic and cardiovascular surgeon     Volume:  58     ISSN:  1439-1902     ISO Abbreviation:  Thorac Cardiovasc Surg     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-14     Completed Date:  2010-03-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7903387     Medline TA:  Thorac Cardiovasc Surg     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  8-10     Citation Subset:  IM    
Department of Cardiac Surgery, Campus Universit?tsklinikum Schleswig-Holstein, L?beck, Germany.
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MeSH Terms
Antibiotics, Antineoplastic / adverse effects*
Doxorubicin / adverse effects*
Heart Failure / chemically induced*,  surgery*
Heart Transplantation
Heart-Assist Devices
Treatment Outcome
Reg. No./Substance:
0/Antibiotics, Antineoplastic; 23214-92-8/Doxorubicin

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