| Surgical treatment of bisphosphonate-associated osteonecrosis of the jaw: Technical report and follow up of 21 patients. | |
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MedLine Citation:
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PMID: 22336489 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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INTRODUCTION: Bisphosphonates are used to reduce skeletal related events in patients with bone consuming diseases such as osteoporosis and bone metastases. However recently there has been an increased awareness of bisphosphonate-associated necrosis of the jaws (BP-ONJ). Many authors propose conservative management in these cases but invariably the problem is not treated successfully allowing the bone defect to worsen. Recently there has been a move to treat this problem surgically. The aim of this retrospective study was to provide a surgical solution for patients suffering from BP-ONJ. MATERIALS AND METHODS: All patients presenting with BP-ONJ were treated with bone debridement of the affected area and multilayer wound closure. The considered variables were: gender, age, underlying diagnosis, type of bisphosphonate (BP) used, duration of bisphosphonate use, route of administration, location of the osteonecrosis, clinical symptoms, association with dental treatment and surgical outcome. RESULTS: Nineteen cases of a total of 21 demonstrated no recurrence of osteonecrosis during follow up (Mean 16 months - Range 12-24 months). One patient with a bilateral defect showed a dehiscence on one side and a small fistula on the contralateral side 6 weeks post-operatively and required revision surgery. Another patient developed a fistula after 4 weeks that was treated successfully with antibiotics and curettage. No patients had evidence of exposed bone, bland mucosa nor pain at the surgical site. CONCLUSION: The technique described can be recommended for patients with BP-ONJ if a conservative treatment fails. |
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Authors:
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Pit Jacob Voss; Joel Joshi Oshero; Alice Kovalova-Müller; Egle Alina Veigel Merino; Sebastian Sauerbier; Jamil Al-Jamali; Juliana Lemound; Marc Christian Metzger; Rainer Schmelzeisen |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-13 |
Journal Detail:
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Title: Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery Volume: - ISSN: 1878-4119 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8704309 Medline TA: J Craniomaxillofac Surg Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Oral and Maxillofacial Surgery, University Hospital Freiburg (Head: Prof. Dr. Dr. Rainer Schmelzeisen), Hugstetter St. 55, 79106 Freiburg im Breisgau, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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