Document Detail

Surgical trauma and vein graft failure: further evidence for a role of ET-1 in graft occlusion.
MedLine Citation:
PMID:  15838269     Owner:  NLM     Status:  MEDLINE    
The saphenous vein (SV) is the most commonly used conduit for coronary artery bypass surgery. However, using traditional techniques, the occlusion rate for the SV is high, with over 50% of grafts failing within 10 years. In conventional coronary artery bypass surgery the SV is exposed to considerable damage during preparation for grafting. Recently, an increased graft patency has been described using a 'no-touch' technique, whereby the vein is prepared with minimal vascular trauma. There is evidence that the success of this form of coronary artery bypass surgery is a result, at least in part, of the retention of tissue-derived nitric oxide. We have examined the effects of conventional SV harvesting on vessel morphology, cell proliferation, endothelin-1 and its receptors. Considerable damage was observed in veins prepared using conventional surgery compared to 'no-touch' veins. The vessel wall exhibited evidence of surgical trauma, with regions of denudation of the luminal endothelium caused by distension. Endothelin-1 and endothelin-A receptors were present at subintimal regions of conventional SV segments where proliferating cells were identified. Endothelial endothelin-B receptors were also revealed that were absent at areas of distension-induced damage to the endothelium. These results suggest that endothelin-1 plays a role in vein graft failure, predominantly via the endothelin-A receptor.
Michael Dashwood; Radhi Anand; Andrzej Loesch; Domingos Souza
Related Documents :
11472049 - Long-term results of infrainguinal arterial reconstruction with spliced veins are equal...
527039 - Demonstration of an inadvertently created aorto-coronary venous anastomosis: evidence a...
8080499 - Posterior approach to the peroneal artery.
7963109 - High stress regions in saphenous vein bypass graft atherosclerotic lesions.
8227109 - Femoropopliteal and femorotibial greater saphenous vein "in situ" reconstructions in no...
993249 - Brachial artery to brachial vein preserved vein allograft fistulas for hemodialysis.
10656909 - Treatment of chronic type b aortic dissection with endovascular stent-graft placement.
24996709 - Upgrading redo coronary artery bypass graft by recycling in situ arterial graft.
21732229 - A preclinical study of the safety and efficacy of occlusin™ 500 artificial embolizati...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  44 Suppl 1     ISSN:  1533-4023     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2005-04-19     Completed Date:  2008-11-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S16-9     Citation Subset:  IM    
Department of Clinical Biochemistry, Royal Free and University College Medical School, London, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cell Proliferation
Coronary Artery Bypass / methods*
Endothelin-1 / analysis*
Endothelium, Vascular / chemistry,  injuries*,  transplantation,  ultrastructure
Graft Occlusion, Vascular / etiology*,  metabolism,  pathology
Microscopy, Electron, Transmission
Receptor, Endothelin A / analysis*
Receptor, Endothelin B
Saphenous Vein / chemistry,  injuries*,  transplantation,  ultrastructure
Tissue and Organ Harvesting / adverse effects*
Treatment Failure
Grant Support
//British Heart Foundation
Reg. No./Substance:
0/Endothelin-1; 0/Receptor, Endothelin A; 0/Receptor, Endothelin B

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Expression of endothelin receptors in the brain of SHR-SP and effects of an endothelin blocker.
Next Document:  Brain expression of VEGF and its receptors in SHR-SP and effects of an endothelin blocker.