Document Detail

Surgical therapy of lesions within the hypothalamic region.
MedLine Citation:
PMID:  3993448     Owner:  NLM     Status:  MEDLINE    
On one hand pituitary microadenomas with autonomous character and those, which had been influenced by hypothalamic disorders, are summarized and discussed. On the other hand, the neurosurgical management of tumours, adjacent to or involved with the hypothalamus, are described. Endocrinologically active pituitary adenomas are characterized by their hormone excess of ACTH, GH, and prolactin. In Cushing's disease endocrine and clinical remission occurred in 74%. 3 patients out of this group showed a reincrease of ACTH after a period of remission, indicating a possible hypothalamic influence. In acromegaly the hypothalamic influence is also discussed. One patient with an ectopic GRF-producing tumour showing a reincrease of GH levels after successful transsphenoidal adenomectomy has been described. In microprolactinomas, 7 patients out of 45 showed a reincrease of prolactin-levels after a period of normalization, we also discussed hypothalamic disorders. Tumours with suprasellar extension such as macroadenomas without endocrine activity and meningiomas are removed nowadays with minimal risk for the life of the patients. In craniopharyngiomas radical excision is accompanied by a high risk of hypothalamic defects caused by mechanical lesions and possible secondary vasospasm. Finally the excision of a hamartoma growing from the floor of the third ventricle into the interpeduncular cistern is discussed. Up to now the successful excision could be documented by endocrinological data, which give no sign of further growth of the hamartoma.
R Fahlbusch; U Schrell
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta neurochirurgica     Volume:  75     ISSN:  0001-6268     ISO Abbreviation:  Acta Neurochir (Wien)     Publication Date:  1985  
Date Detail:
Created Date:  1985-06-06     Completed Date:  1985-06-06     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0151000     Medline TA:  Acta Neurochir (Wien)     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  125-35     Citation Subset:  IM    
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MeSH Terms
Acromegaly / surgery
Adenoma / surgery
Astrocytoma / surgery
Brain Neoplasms / surgery
Craniopharyngioma / surgery
Cushing Syndrome / surgery
Follow-Up Studies
Hypothalamic Diseases / surgery*
Hypothalamic Hormones / blood
Meningeal Neoplasms / surgery
Meningioma / surgery
Pituitary Hormones / blood
Pituitary Neoplasms / surgery
Prolactin / secretion
Puberty, Precocious / surgery
Reg. No./Substance:
0/Hypothalamic Hormones; 0/Pituitary Hormones; 9002-62-4/Prolactin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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