Document Detail

Surgical therapy for Wolff-Parkinson-White syndrome in patients with bronchial asthma.
MedLine Citation:
PMID:  8634847     Owner:  NLM     Status:  MEDLINE    
The surgical therapy for Wolff-Parkinson-White syndrome in patients with bronchial asthma was studied. Between 1974 and 1992, 447 patients with Wolff-Parkinson-White syndrome were treated, seven of whom had associated severe bronchial asthma. Supraventricular tachyarrhythmias were induced on occasion by bronchodilating agents such as beta-receptor agonists or theophylline preparations. High-dose steroids were required for acute bronchospasm in three patients, despite possibly leading to cardiac dysfunction. Beta-blockers therapy for Wolff-Parkinson-White syndrome can induce bronchospasm; in patients with Wolff-Parkinson-White syndrome and bronchial asthma, pharmacological agents used to treat one condition may exacerbate the other. Therefore, a non-pharmacological therapy was performed, namely surgical division of the accessory conduction pathway via an endocardial approach, in all seven asthmatic patients with Wolff-Parkinson- White syndrome. In all cases, division of the accessory conduction pathway resulted in disappearance of the delta wave, and there were no further tachyarrhythmias either at rest or after administration of bronchodilators. Since surgery, bronchial asthma has been effectively controlled with standard drug therapy in all patients. Non-pharmacological therapy is recommended for patients with Wolff-Parkinson-White syndrome and bronchial asthma.
H Ohtake; T Misaki; Y Matsunaga; M Tubota; M Kawasuji; Y Watanabe
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cardiovascular surgery (London, England)     Volume:  4     ISSN:  0967-2109     ISO Abbreviation:  Cardiovasc Surg     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-07-08     Completed Date:  1996-07-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9308765     Medline TA:  Cardiovasc Surg     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  53-6     Citation Subset:  IM    
Department of Surgery, Kanazawa University, School of Medicine, Japan.
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MeSH Terms
Adrenergic beta-Agonists / adverse effects
Adrenergic beta-Antagonists / adverse effects
Asthma / complications*,  drug therapy,  physiopathology
Bronchial Spasm / chemically induced
Bronchodilator Agents / adverse effects
Follow-Up Studies
Heart Conduction System / surgery
Middle Aged
Tachycardia, Supraventricular / chemically induced,  surgery
Theophylline / adverse effects
Treatment Outcome
Wolff-Parkinson-White Syndrome / complications,  drug therapy,  physiopathology,  surgery*
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Adrenergic beta-Antagonists; 0/Bronchodilator Agents; 58-55-9/Theophylline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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