Document Detail

Surgical strategy for large or malignant endocrine pancreatic tumors.
MedLine Citation:
PMID:  11038206     Owner:  NLM     Status:  MEDLINE    
Endocrine pancreatic tumors (EPTs) are rare but have a remarkably better prognosis than adenocarcinoma of the pancreas. Patients with EPTs benefit from surgical and medical therapy, which may alleviate symptoms due to hormonal excess and increase survival. Patients with large or malignant EPTs with infiltrative disease may suffer from local complications, including gastrointestinal bleeding and obstruction and involvement of the superior mesenteric (SMV) and portal (PV) veins. Among 31 patients with operable and large or malignant EPTs, 7 had hormone-producing syndromes (insulin, glucagon), and 24 had clinically nonfunctioning EPTs. Surgery in these patients included vascular reconstruction of the SMV/PV (n = 4), resection of infiltrated adjacent organs (n = 5; stomach, transverse colon), or resection of concomitant liver metastases (n = 3). Four patients with conspicuously large insulinomas, and three with glucagonoma were successfully operated on with alleviation of hormonal symptoms. Among the 24 nonfunctioning EPTs, 5 patients had been explored earlier and their tumors judged inoperable due to locally invasive disease or misdiagnosis as pancreatic adenocarcinoma. The operations were performed with no mortality and low morbidity. We conclude that large and malignant EPTs with limited spread of disease may benefit from a combination of medical and surgical therapy.
P Hellman; M Andersson; J Rastad; C Juhlin; S Karacagil; B Eriksson; B Skogseid; G Akerström
Related Documents :
23039276 - Dorsal vein complex preserving technique for intrafascial nerve-sparing laparoscopic ra...
20362786 - The evidence for technical considerations in pancreatic resections for malignancy.
12029006 - Preservation of urine for flow cytometric and visual microscopic testing.
17933666 - The laparoscopic approach toward hyperinsulinism in children.
18712696 - The safety of outpatient uppp for obstructive sleep apnea: a retrospective review of 40...
1652746 - Prevalence of dental abscess in a population of children with vitamin d-resistant rickets.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  World journal of surgery     Volume:  24     ISSN:  0364-2313     ISO Abbreviation:  World J Surg     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2000-12-21     Completed Date:  2000-12-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7704052     Medline TA:  World J Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1353-60     Citation Subset:  IM    
Department of Surgery, University Hospital, S-751 85 Uppsala, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / administration & dosage
Biopsy, Needle
Carcinoma, Pancreatic Ductal / diagnosis*,  drug therapy,  mortality,  surgery*
Follow-Up Studies
Magnetic Resonance Imaging
Middle Aged
Neoplasm Staging
Pancreatectomy / adverse effects,  methods*
Pancreatic Neoplasms / diagnosis*,  drug therapy,  mortality,  surgery*
Retrospective Studies
Severity of Illness Index
Survival Rate
Tomography, X-Ray Computed
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Study of three patients with congenital adrenal hyperplasia treated by bilateral adrenalectomy.
Next Document:  Parathyroid xenotransplantation without immunosuppression in experimental hypoparathyroidism: long-t...