| Surgical and radiologic staging of cervical cancer. | |
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MedLine Citation:
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PMID: 19952745 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: The roles of radiologic and surgical staging in cervical carcinoma have been controversial. This review updates publications in this area. RECENT FINDINGS: Conventional computed tomography or MRI has been suboptimal in detecting depth of cervical stromal invasion and nodal metastasis.18-Fluorodeoxyglucose PET or integrated PET/computed tomography (thereafter as PET collectively) is valuable for assessing prognosis, treatment response after the completion of concurrent chemoradiation, documented recurrent cervical cancer, and posttreatment unexplained tumor marker elevation. Results of MRI using nanoparticle contrast media, higher Tesla machines, or diffusion-weighted imaging without contrast may be promising. Although surgical staging is feasible, level 1 evidence is still lacking for survival benefit before definitive radiotherapy/chemoradiation in locally advanced cervical cancer. A randomized controlled trial of additional PET in MRI-defined pelvic node-positive patients prior to chemoradiation did not show significant survival benefit. SUMMARY: Nonsurgical staging is still the gold standard for advanced cervical cancer treatment planning unless well designed phase III study could show a significant survival benefit of surgical staging. The roles of molecular imaging (new MRI technology or PET with fluorodeoxyglucose or other radiotracers) as an early predictor of response to treatment need more researches. |
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Authors:
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Chyong-Huey Lai; Tzu-Chen Yen; Koon-Kwan Ng |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current opinion in obstetrics & gynecology Volume: 22 ISSN: 1473-656X ISO Abbreviation: Curr. Opin. Obstet. Gynecol. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2009-12-25 Completed Date: 2010-04-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9007264 Medline TA: Curr Opin Obstet Gynecol Country: England |
Other Details:
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Languages: eng Pagination: 15-20 Citation Subset: IM |
Affiliation:
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Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Kueishan, Taoyuan 333, Taiwan. laich46@cgmh.org.tw |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Diffusion Magnetic Resonance Imaging Female Fluorodeoxyglucose F18 / diagnostic use Humans Neoplasm Staging / methods* Positron-Emission Tomography Sentinel Lymph Node Biopsy Uterine Cervical Neoplasms / pathology*, surgery |
| Chemical | |
Reg. No./Substance:
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63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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