Document Detail

Surgical outcomes following laparoscopic adrenalectomy for treatment of Conn's syndrome (primary hyperaldosteronism) between 1999 and 2006.
MedLine Citation:
PMID:  20953222     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Primary hyperaldosteronism is a recognised cause of secondary hypertension with its aetiology most commonly due to a secreting aldosterone adenoma of the adrenal gland. Laparoscopic resection of the adrenal tumour has now become the accepted form of intervention. The aim of this study was to assess the effectiveness of such procedures performed by one surgeon over a 7-year period. METHOD: An observational study was conducted in respect of 33 patients who underwent adrenalectomies for primary hyperaldosteronism between 1999-2006. Information on blood pressure, electrolytes, medications, histology, patient characteristics and patients' perception of benefit was gathered via clinical notes and a patient questionnaire. RESULTS: 33 patients were reviewed. The mean follow-up was 38.4 months. Blood pressure and number of medications all had statistically significant decreases. Systolic blood pressure decreased from 146 mmHg preoperatively to 130 mmHg at final follow-up (p<0.00005). Diastolic blood pressure decreased from 91.0 mmHg preoperatively to 81.5 mmHg (p<0.00005). There was also a significant decrease in number of blood pressure medications from 2.3 preoperatively to 1.0 on average (p<0.00005). Only one patient required potassium at final review. Overall 36% had clinical cure and 50% had significant improvement in terms of blood pressure and medications requirements. CONCLUSION: The results suggest unilateral laparoscopic adrenalectomy is an effective tool in treatment for benign primary hyperaldosteronism caused by aldosterone secreting adenomas.
Andrew Herd; Richard Harman; Eletha Taylor
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2010-10-15
Journal Detail:
Title:  The New Zealand medical journal     Volume:  123     ISSN:  1175-8716     ISO Abbreviation:  N. Z. Med. J.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-18     Completed Date:  2010-11-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401067     Medline TA:  N Z Med J     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  50-6     Citation Subset:  IM    
General Surgery, North Shore Hospital, Auckland, New Zealand.
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MeSH Terms
Adrenalectomy / methods*
Blood Pressure / physiology*
Follow-Up Studies
Hyperaldosteronism / physiopathology,  surgery*
Middle Aged
Retrospective Studies
Time Factors
Treatment Outcome

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