Document Detail


Surgical outcome of patients with mesial temporal lobe epilepsy related to hippocampal sclerosis.
MedLine Citation:
PMID:  18205819     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Seizure outcome in mesial temporal lobe epilepsy related to hippocampal sclerosis (MTLE-HS) that was evaluated according to a noninvasive protocol was assessed in 165 patients and reported using both Engel's and ILAE classifications. The mean postoperative follow-up was 5.0 +/- 2.7 years. At the end of first year, 77.1% of patients were in Engel-I, and 52.7% were in ILAE-I. Antiepileptic drugs (AEDs) were discontinued in 41 patients (42.7%), all remained seizure-free for >or= 2 years that could be accepted as "cure." Thirty-six patients had recurrences, 19 had running-down phenomena. Anterior temporal lobectomy (ATL) was performed in 27 patients with a better outcome when compared to patients operated by selective anterior hippocampectomy. Clinical risk factors for better and worse outcome, which show some similarity in different reports, seem to veil the main reason, which is the accurate delineation of epileptogenic zone considering the presence of different subgroups and underlying developmental pathologies.
Authors:
Ciğdem Ozkara; Mustafa Uzan; Gülçin Benbir; Naz Yeni; Büge Oz; Lütfü Hanoğlu; Naci Karaağac; Emin Ozyurt
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2008-01-18
Journal Detail:
Title:  Epilepsia     Volume:  49     ISSN:  0013-9580     ISO Abbreviation:  Epilepsia     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-27     Completed Date:  2008-05-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  United States    
Other Details:
Languages:  eng     Pagination:  696-9     Citation Subset:  IM    
Affiliation:
Department of Neurology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey. cigdemoz@istanbul.edu.tr
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Factors
Anterior Temporal Lobectomy
Child
Disease-Free Survival
Epilepsy, Temporal Lobe / classification,  pathology*,  surgery*
Female
Follow-Up Studies
Hippocampus / pathology*,  surgery
Humans
Male
Middle Aged
Outcome Assessment (Health Care)
Prognosis
Recurrence
Risk Factors
Sclerosis / pathology
Temporal Lobe / pathology,  surgery
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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