Document Detail

Surgical necrotizing enterocolitis and intraventricular hemorrhage in premature infants below 1000 g.
MedLine Citation:
PMID:  16863849     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/PURPOSE: Infants with very low birth weight are at increased risk for both intraventricular hemorrhage (IVH) and necrotizing enterocolitis (NEC). IVH often progresses in severity after initial diagnosis and causes severe neurological morbidity and mortality. The authors examined the role of NEC in the progression of IVH in these infants. METHODS: The authors conducted a retrospective case-control study using data from the University of Maryland neonatal intensive care unit database between 1991 and 2003. From a cohort of 957 infants with very low birth weight, 53 pairs of infants labeled as IVH progression versus controls were selected and closely matched in respect to their gestational age and birth weight. Charts from these infants were reviewed to identify risk factors contributing to IVH progression. RESULTS: Infants with IVH progression were significantly more likely to suffer from NEC (odds ratio, 3.6), whereas infants with surgical NEC showed a greater association with IVH progression (odds ratio, 5.33). Association with thrombocytopenia was also seen (odds ratio, 3.33). Sepsis showed trend toward significance (odds ratio, 1.9; P = .095) for progression of IVH. CONCLUSION: Surgical NEC showed the greatest risk for IVH progression. NEC and thrombocytopenia also appear to be risk factors for IVH progression.
Howard C Jen; Jerome J Graber; J Laurance Hill; Samuel M Alaish; Roger W Voigt; Eric D Strauch
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric surgery     Volume:  41     ISSN:  1531-5037     ISO Abbreviation:  J. Pediatr. Surg.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-25     Completed Date:  2006-09-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0052631     Medline TA:  J Pediatr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1425-30     Citation Subset:  IM    
Division of Pediatric Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
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MeSH Terms
Case-Control Studies
Disease Progression
Enterocolitis, Necrotizing / epidemiology,  etiology*
Infant, Newborn
Infant, Premature*
Infant, Very Low Birth Weight*
Intracranial Hemorrhages / epidemiology,  etiology*
Retrospective Studies
Risk Factors
Thrombocytopenia / complications

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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