Document Detail

Surgical management of islet-cell adenoma in infancy.
MedLine Citation:
PMID:  211657     Owner:  NLM     Status:  MEDLINE    
Persistent neonatal hypoglycemia is a potentially serious condition which should be recognized promptly, investigated thoroughly, and treated expeditiously. Islet-cell adenoma causing hypoglycemia in infancy is very unusual. Only 23 cases have been reported in the literature. This report documents eight cases of our own and summarizes diagnostic methods, proper medical preparation, and fundamental surgical management. Prompt surgical intervention is emphasized, as this will relieve hypoglycemia and may be important in preventing irreversible central nervous system damage. We are of the opinion that any infant with unremitting hypoglycemia, a high corrected insulin/glucose ratio, and failure to respond to maximum diazoxide therapy will require partial pancreatectomy. Identification of the adenoma at the time of operation is unlikely, and blind pancreatectomy and/or reoperation is not unusual.
R H Rich; L P Dehner; K Okinaga; L C Deeb; R A Ulstrom; A S Leonard
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Surgery     Volume:  84     ISSN:  0039-6060     ISO Abbreviation:  Surgery     Publication Date:  1978 Oct 
Date Detail:
Created Date:  1978-11-29     Completed Date:  1978-11-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0417347     Medline TA:  Surgery     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  519-26     Citation Subset:  AIM; IM    
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MeSH Terms
Adenoma / pathology,  surgery*
Adenoma, Islet Cell / pathology,  surgery*
Infant, Newborn
Infant, Newborn, Diseases / pathology,  surgery*
Pancreatic Neoplasms / pathology,  surgery*

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