Document Detail

Surgical management of hepatocellular carcinoma. Liver resection and liver transplantation.
MedLine Citation:
PMID:  17676197     Owner:  NLM     Status:  MEDLINE    
Although remarkable progress has been made in the treatment of hepatocellular carcinoma HCC, local control is still the most important consideration. Liver resection is and will continue to be the first-line therapeutic modality for local control of a primary HCC, including cases with intrahepatic metastases. For a large HCC, or multiple HCCs with vascular invasion, aggressive liver resection must be pursued. In cases with poor liver functional reserve, liver transplantation would be a good therapeutic option, after considering age, and tumor-related factors. To prevent deterioration of the liver function should be the second priority in the treatment of HCC. As for liver resection, extensive removal of the non-cancerous parenchyma, such as lobectomy and hemihepatectomy, should be avoided as much as possible. Anatomic resection, which involves systematic elimination of the main tumor with its minute metastases and preserves liver function, is strongly recommended. The treatment algorithm, which is based on evidence picked up from published papers, is now available and useful to determine the therapeutic choice depending on the tumor- and liver function-related conditions.
Kiyoshi Hasegawa; Norihiro Kokudo; Masatoshi Makuuchi
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Saudi medical journal     Volume:  28     ISSN:  0379-5284     ISO Abbreviation:  Saudi Med J     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-06     Completed Date:  2007-11-08     Revised Date:  2008-06-23    
Medline Journal Info:
Nlm Unique ID:  7909441     Medline TA:  Saudi Med J     Country:  Saudi Arabia    
Other Details:
Languages:  eng     Pagination:  1171-9     Citation Subset:  IM    
Department of Surgery, Hepato-Biliary-Pancreatic Surgery Division, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
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MeSH Terms
Carcinoma, Hepatocellular / pathology,  surgery*
Liver Neoplasms / pathology,  surgery*
Liver Transplantation*

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