Document Detail

Surgical left ventricular radius enlargement by patch insertion on the beating heart: a new experimental aneurysm model.
MedLine Citation:
PMID:  22523129     Owner:  NLM     Status:  MEDLINE    
We presented a novel experimental aneurysm model for studies in left ventricular (LV) reconstruction techniques and assessed LV function. In eight pigs, the LV radius and geometry were enlarged surgically on the beating heart by inserting an aortic allograft construct. Haemodynamics and LV dimensions were assessed by echocardiography at baseline and under dobutamine stress. Surgery was successfully performed without lethal blood loss or arrhythmias. LV end-diastolic and end-systolic short-axis areas increased from 13.0 ± 1.7 to 17.0 ± 4.3 cm(2) (P = 0.001) and from 4.0 ± 0.9 to 13.0 ± 2.6 cm(2) (P = 0.001), respectively. Stroke volume decreased from 56 ± 11 to 33 ± 16 ml (P = 0.001). Incremental dobutamine infusion concurred with a biphasic response on fractional area shortening. Mitral valve insufficiency ranging from grades 2 to 4 was observed. In the pig, a novel, reproducible aneurysm model for acute cardiac dysfunction was created on the beating heart. Innovative (surgical) strategies for (staged) reconfiguration of the ventricle, e.g. adjustable Dor procedures and stepwise volume restraining cardiac support devices, can be tested for efficacy using this acute model.
Paul F Gründeman; Tycho I G van der Spoel; Paul Steendijk; Frebus van Slochteren; Maarten Jan M Cramer; Pieter A Doevendans; Gerard Pasterkamp
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media     Date:  2012-04-19
Journal Detail:
Title:  Interactive cardiovascular and thoracic surgery     Volume:  15     ISSN:  1569-9285     ISO Abbreviation:  Interact Cardiovasc Thorac Surg     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-22     Completed Date:  2012-10-29     Revised Date:  2013-07-02    
Medline Journal Info:
Nlm Unique ID:  101158399     Medline TA:  Interact Cardiovasc Thorac Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  10-3     Citation Subset:  IM    
Experimental Cardiology Laboratory, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands.
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MeSH Terms
Aorta / transplantation*
Blood Pressure
Cardiac Surgical Procedures*
Cardiotonic Agents / administration & dosage
Disease Models, Animal
Dobutamine / administration & dosage
Heart Aneurysm / etiology*,  physiopathology,  ultrasonography
Heart Rate
Heart Ventricles / physiopathology,  surgery*,  ultrasonography
Mitral Valve Insufficiency / etiology,  physiopathology
Stroke Volume
Transplantation, Homologous
Ventricular Function, Left
Reg. No./Substance:
0/Cardiotonic Agents; 34368-04-2/Dobutamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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