| Surgical left ventricular radius enlargement by patch insertion on the beating heart: a new experimental aneurysm model. | |
| | |
MedLine Citation:
|
PMID: 22523129 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We presented a novel experimental aneurysm model for studies in left ventricular (LV) reconstruction techniques and assessed LV function. In eight pigs, the LV radius and geometry were enlarged surgically on the beating heart by inserting an aortic allograft construct. Haemodynamics and LV dimensions were assessed by echocardiography at baseline and under dobutamine stress. Surgery was successfully performed without lethal blood loss or arrhythmias. LV end-diastolic and end-systolic short-axis areas increased from 13.0 ± 1.7 to 17.0 ± 4.3 cm(2) (P = 0.001) and from 4.0 ± 0.9 to 13.0 ± 2.6 cm(2) (P = 0.001), respectively. Stroke volume decreased from 56 ± 11 to 33 ± 16 ml (P = 0.001). Incremental dobutamine infusion concurred with a biphasic response on fractional area shortening. Mitral valve insufficiency ranging from grades 2 to 4 was observed. In the pig, a novel, reproducible aneurysm model for acute cardiac dysfunction was created on the beating heart. Innovative (surgical) strategies for (staged) reconfiguration of the ventricle, e.g. adjustable Dor procedures and stepwise volume restraining cardiac support devices, can be tested for efficacy using this acute model. |
| | |
Authors:
|
Paul F Gründeman; Tycho I G van der Spoel; Paul Steendijk; Frebus van Slochteren; Maarten Jan M Cramer; Pieter A Doevendans; Gerard Pasterkamp |
Related Documents
:
|
7811559 - Noninvasive identification of anthracycline cardiotoxicity: comparison of 123i-mibg and... 10982699 - Contribution of doppler atrioventricular flow waves to ventricular filling in the human... 21797899 - Cardiac resynchronization therapy optimization using noninvasive cardiac output measure... 19513629 - Evaluation of epirubicin-induced cardiotoxicity by two-dimensional strain echocardiogra... 12174199 - An unusual pulsed-wave tissue doppler pattern in mitral valve prolapse: spikes on systo... 2953229 - Quantification of atrial contribution to left ventricular filling by pulsed doppler ech... 12849679 - Induction of left ventricular remodeling and dysfunction in the recipient heart after d... 7671379 - Normothermic continuous antegrade blood cardioplegia does not prevent myocardial edema ... 12668889 - Nesiritide: a new therapy for the treatment of heart failure. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media Date: 2012-04-19 |
Journal Detail:
|
Title: Interactive cardiovascular and thoracic surgery Volume: 15 ISSN: 1569-9285 ISO Abbreviation: Interact Cardiovasc Thorac Surg Publication Date: 2012 Jul |
Date Detail:
|
Created Date: 2012-06-22 Completed Date: 2012-10-29 Revised Date: 2013-04-16 |
Medline Journal Info:
|
Nlm Unique ID: 101158399 Medline TA: Interact Cardiovasc Thorac Surg Country: England |
Other Details:
|
Languages: eng Pagination: 10-3 Citation Subset: IM |
Affiliation:
|
Experimental Cardiology Laboratory, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands. p.f.grundeman@umcutrecht.nl |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Aorta / transplantation* Blood Pressure Cardiac Surgical Procedures* Cardiotonic Agents / administration & dosage Disease Models, Animal Dobutamine / administration & dosage Heart Aneurysm / etiology*, physiopathology, ultrasonography Heart Rate Heart Ventricles / physiopathology, surgery*, ultrasonography Mitral Valve Insufficiency / etiology, physiopathology Stroke Volume Swine Transplantation, Homologous Ventricular Function, Left |
| Chemical | |
Reg. No./Substance:
|
0/Cardiotonic Agents; 34368-04-2/Dobutamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Sexual Systems and Life History of Barnacles: A Theoretical Perspective.
Next Document: Recovery of Endothelial Function After Sirolimus-Eluting Stent Implantation: A Pilot Study.