| Surgical influence of pancreatectomy on the function and count of circulating dendritic cells in patients with pancreatic cancer. | |
| | |
MedLine Citation:
|
PMID: 16167144 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Dendritic cells (DCs) are important for an immune surveillance. Myeloid DCs (DC1) are important for an effective antitumor immune system. The function and count of circulating DC1 (cDC1) in hosts with a malignant tumor would be defective. This study focused on analyzing the immunological features of cDC1 in patients with pancreatic cancer during the perioperative period. MATERIALS AND METHODS: Thirty-two pancreatic cancer patients who underwent pancreatectomy and 18 age-matched healthy individuals as controls were enrolled in this study. The perioperative cDC count, the stimulatory capacity of cDC1 against allogeneic T cells and TGF-beta1 level in the serum were measured. The cDC count was measured at 12 months after the operation. RESULTS: The preoperative cDC1/cDC2 ratio, cDC1 count, and stimulatory capacity of cDC1 were impaired in patients in comparison to controls (P<0.05). The serum TGF-beta1 level was significantly higher in patients than controls (P<0.001). The stimulatory capacity of cDC1 recovered after pancreatectomy (P<0.05). The serum TGF-beta1 level significantly decreased after the operation (P<0.05); however, they were still significantly higher than controls (P<0.05). Although the cDC1/cDC2 ratio and the cDC1 count did not increase after the pancreatectomy, they recovered as the controls' level at 12 months after the pancreatectomy in disease-free patients (P<0.05) and the serum TGF-beta1 level in those patients at 12 months after the operation significantly decreased compared with those at the postoperative period (P<0.05). CONCLUSION: Surgical resection of pancreatic cancer could be associated with improved cDC1 function. When a patient remained disease free, the recovery of cDC1 counts was observed approximately 12 months after pancreatectomy. Further strategy will be needed to improve immune function in patients with pancreatic cancer. |
| | |
Authors:
|
Kanji Takahashi; Hideyoshi Toyokawa; Soichiro Takai; Sohei Satoi; Hiroaki Yanagimoto; Naoyoshi Terakawa; Hiroshi Araki; A-Hon Kwon; Yasuo Kamiyama |
Related Documents
:
|
11560784 - Autoimmune-related pancreatitis. 22705264 - Clinical and biochemical validation of two endophenotypes of schizophrenia defined by l... 21676364 - Increased electronegative ldl and decreased antibodies against electronegative ldl leve... 18585674 - Significance of splenic vein thrombosis in chronic pancreatitis. 18828014 - Thyroid uptake of 67ga-citrate is associated with thyroid autoimmunity and hypothyroidi... 9267974 - Olfactory dysfunction for pyridine and dementia progression in alzheimer disease. |
Publication Detail:
|
Type: Comparative Study; Journal Article Date: 2005-09-16 |
Journal Detail:
|
Title: Cancer immunology, immunotherapy : CII Volume: 55 ISSN: 0340-7004 ISO Abbreviation: Cancer Immunol. Immunother. Publication Date: 2006 Jul |
Date Detail:
|
Created Date: 2006-03-28 Completed Date: 2006-06-13 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8605732 Medline TA: Cancer Immunol Immunother Country: Germany |
Other Details:
|
Languages: eng Pagination: 775-84 Citation Subset: IM |
Affiliation:
|
Department of Surgery, Kansai Medical University, 10-15, Fumizono, Moriguchi, 570-8507, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Blood Cell Count* Case-Control Studies Dendritic Cells / immunology* Disease-Free Survival Female Follow-Up Studies Humans Killer Cells, Natural / immunology Lymphocyte Activation / drug effects Lymphocyte Culture Test, Mixed Male Middle Aged Pancreatectomy* Pancreatic Neoplasms / blood, immunology, surgery* Phytohemagglutinins / pharmacology Postoperative Period T-Lymphocytes / drug effects, immunology Transforming Growth Factor beta / blood Transforming Growth Factor beta1 |
| Chemical | |
Reg. No./Substance:
|
0/Phytohemagglutinins; 0/TGFB1 protein, human; 0/Transforming Growth Factor beta; 0/Transforming Growth Factor beta1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Proton exchange membrane and electrode surface areas as factors that affect power generation in micr...
Next Document: Nitrogen supply differentially affects litter decomposition rates and nitrogen dynamics of sub-arcti...