Document Detail

Surgical infections and prophylactic antibiotics: 341 consecutive cases of gallbladder surgery in the era of laparoscopic surgery.
MedLine Citation:
PMID:  9448126     Owner:  NLM     Status:  MEDLINE    
HYPOTHESIS: This study was undertaken to assess the use of prophylactic antibiotics (PA) in laparoscopic and open cholecystectomy with respect to the postoperative infection rate and the established criteria for PA use. METHODS: A total of 341 consecutive cases for 1994 were retrospectively analyzed. PA use was deemed appropriate if the patient: was over 70 years of age, had common duct stones, jaundice, or acute cholecystitis. RESULTS: The infection rate of patients having an open cholecystectomy was significantly greater than the laparoscopic group (12.9% versus 1.8%, p < .001). In the laparoscopic group of patients who met the criteria for PA and received PA there were no infections as compared with those who had criteria for but did not receive PA (0% versus 22%, p < .05). Only 27% of all elective cholecystectomy patients received cefazolin while 73% of patients received extended spectrum antibiotics. CONCLUSIONS: In 63.2% of patients antibiotics were used with no indication for PA. In 73% of patients, an extended spectrum drug was used when a less expensive and narrower spectrum agent would have sufficed. Open cholecystectomy has a significantly higher infectious rate than closed cholecystectomy.
N Garcia; S Kapur; J McClane; J M Davis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of laparoendoscopic & advanced surgical techniques. Part A     Volume:  7     ISSN:  1092-6429     ISO Abbreviation:  J Laparoendosc Adv Surg Tech A     Publication Date:  1997 Jun 
Date Detail:
Created Date:  1998-02-12     Completed Date:  1998-02-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9706293     Medline TA:  J Laparoendosc Adv Surg Tech A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  157-62     Citation Subset:  IM    
Department of Surgery, Cornell University Medical College, New York, New York 10021, USA.
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MeSH Terms
Antibiotic Prophylaxis* / utilization
Cephalosporins / therapeutic use
Cholecystectomy, Laparoscopic*
Middle Aged
Penicillins / therapeutic use
Piperacillin / therapeutic use
Retrospective Studies
Surgical Wound Infection / epidemiology,  prevention & control*
Reg. No./Substance:
0/Cephalosporins; 0/Penicillins; 61477-96-1/Piperacillin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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