Document Detail

Surgical induction of chorioretinal venous anastomosis in ischaemic central retinal vein occlusion: a non-randomised controlled clinical trial.
MedLine Citation:
PMID:  15615749     Owner:  NLM     Status:  MEDLINE    
AIM: To evaluate the safety and efficacy of surgical induction of chorioretinal venous anastomosis in the management of ischaemic central retinal vein occlusion (CRVO).
METHODS: In a comparative clinical trial, 28 patients with ischaemic CRVO were included, of whom 18 who declined surgery were considered as controls. The 10 surgical cases underwent standard vitrectomy with incisions into the choroids adjacent to the partially cut major retinal veins. Mersilene suture insertion was done to induce chorioretinal venous shunt. Mild endolaser was applied. Patients were followed up for 6-18 (mean 10) months.
RESULTS: Clinical success in shunt development was 90%. Surgical cases had a significantly better visual acuity improvement compared with controls (mean difference: 1.5 logMAR, p = 0.001) with 80% of them showing improvement (compared with 28% of the controls, p = 0.016). Neovascularisation developed in 39% of the control group compared with 0% of the surgical cases (p = 0.03). In multivariate analysis, surgery remained the sole significant predictor of visual improvement. There were three re-operations for vitreous cavity haemorrhage, cataract, and retinal detachment.
CONCLUSIONS: Surgical induction of chorioretinal venous anastomosis may result in visual acuity improvement and prevent neovascularisation in ischaemic CRVO. Randomised studies are needed to compare the current study modality with the natural course of CRVO and emerging procedures, such as optic neurotomy, in the management of ischaemic CRVO.
A Mirshahi; R Roohipoor; A Lashay; S F Mohammadi; M R Mansouri
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  The British journal of ophthalmology     Volume:  89     ISSN:  0007-1161     ISO Abbreviation:  Br J Ophthalmol     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2004-12-23     Completed Date:  2005-01-18     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  0421041     Medline TA:  Br J Ophthalmol     Country:  England    
Other Details:
Languages:  eng     Pagination:  64-9     Citation Subset:  IM    
Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, PO Box 14155-7146, Tehran, Iran.
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MeSH Terms
Aged, 80 and over
Anastomosis, Surgical / methods
Choroid / surgery*
Choroidal Neovascularization / etiology,  prevention & control
Fluorescein Angiography / methods
Middle Aged
Postoperative Complications / etiology,  prevention & control
Retina / surgery*
Retinal Neovascularization / etiology,  prevention & control
Retinal Vein Occlusion / complications,  physiopathology,  surgery*
Treatment Outcome
Visual Acuity / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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