Document Detail

Surgical excision of heterotopic bone after hip surgery followed by oral indomethacin application: is there a clinical benefit for the patient?
MedLine Citation:
PMID:  10392508     Owner:  NLM     Status:  MEDLINE    
The clinical effect of surgical excision of heterotopic bone after hip surgery in combination with an oral indomethacin application was analysed in 21 patients in a retrospective study. Indomethacin (3 x 50 mg) was administered after the first postoperative day for a period of 6 weeks. To avoid gastrointestinal side-effects, a mucoprotectivum (sucralfat, 3 x 1 g) was also applied. One year after surgery, 19 patients (90.4%) had excellent relief of pain, the average improvement of flexion was 40 degrees, of abduction 13 degrees, of internal rotation 8 degrees and of external rotation 14 degrees. Only one patient (4.8%) suffered a recurrence of heterotopic bone formation, and in one patient (4.8%) we observed gastrointestinal side-effects. Thus, we recommend surgical excision of heterotopic bone followed by oral indomethacin therapy as a convenient and reliable strategy to prevent new heterotopic bone formation after hip surgery.
M Wick; E J Müller; M P Hahn; G Muhr
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of orthopaedic and trauma surgery     Volume:  119     ISSN:  0936-8051     ISO Abbreviation:  Arch Orthop Trauma Surg     Publication Date:  1999  
Date Detail:
Created Date:  1999-08-05     Completed Date:  1999-08-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9011043     Medline TA:  Arch Orthop Trauma Surg     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  151-5     Citation Subset:  IM    
Department of Surgery and Traumatology, Berufsgenossenschaftliche Kliniken Bergmannsheil, Bochum, Germany.
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MeSH Terms
Aged, 80 and over
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
Arthroplasty, Replacement, Hip*
Hip Joint / physiopathology,  radiography
Indomethacin / therapeutic use*
Middle Aged
Ossification, Heterotopic / prevention & control,  radiography,  surgery*
Postoperative Period
Range of Motion, Articular
Retrospective Studies
Treatment Outcome
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 53-86-1/Indomethacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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