Document Detail

Surgical debridement plus topical cyclosporine A in the treatment of vernal shield ulcers.
MedLine Citation:
PMID:  23058030     Owner:  NLM     Status:  Publisher    
Vernal Keratoconjunctivitis (VKC) is a severe chronic bilateral inflammation of the ocular surface characterized by seasonal exacerbations. Long-term prognosis is generally good; however, 6 percent develop sequelae responsible for permanent visual impairment. Corneal involvement is almost always present, consisting of punctate keratitis, shield ulcers (3-11 percent) and late corneal neovascularization. In recent years, topical cyclosporine A preparations at 2 percent in oil or at 1 percent in polyvinyl alcohol, have been successfully proposed for long term VKC treatments. It has been previously proven that medical treatment is not always sufficient, especially when it is employed to treat shield ulcer plaques. In such conditions, surgery may be effective for avoiding long term complications such as amblyopia, strabismus, infections and corneal perforation. In this paper, we show the efficacy of surgical debridement by means of simple scraping associated with topical cyclosporine treatment for the management of vernal shield ulcers complicated with plaques.
R Caputo; N Pucci; F Mori; C De Libero; L Di Grande; G M Bacci
Publication Detail:
Journal Detail:
Title:  International journal of immunopathology and pharmacology     Volume:  25     ISSN:  0394-6320     ISO Abbreviation:  Int J Immunopathol Pharmacol     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-10-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8911335     Medline TA:  Int J Immunopathol Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  775-780     Citation Subset:  -    
Pediatric Ophthalmology Unit, Anna Meyer Children’s Hospital, Department of Pediatrics, University of Florence, Italy.
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