| Surgical approaches for the prevention and treatment of type 2 diabetes mellitus. | |
| | |
MedLine Citation:
|
PMID: 19829176 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Lifestyle modifications and pharmacologic therapy have been the mainstays of treatment for patients with type 2 diabetes mellitus. Bariatric surgery, originally designed as a weight loss treatment, has been proven to ameliorate and even cure diabetes. The significant improvement in glycemic control found after bariatric surgery in patients with diabetes often precedes major weight loss. Therefore, a weight-independent mechanism has been thought to initiate this amelioration in glucose control. Reviews of the recent literature question the goal of bariatric surgery, not only to treat obesity through restriction and malabsorption, but also as a possible treatment for diabetes regardless of the degree of obesity. Procedures such as Roux-en-Y gastric bypass, adjustable gastric banding, and biliopancreatic diversion have proven to be extremely effective in controlling diabetes mellitus. Mechanisms explaining the effectiveness of weight reduction surgery include effects on incretins, ghrelin secretion, and insulin sensitivity. Some centers have been performing gastric bypass surgeries on patients with a lower body mass index than that recommended by current NIH guidelines. New considerations for recommending bypass surgery are warranted as the indications for antiobesity surgeries grow to encompass both the treatment and cure of diabetes. |
| | |
Authors:
|
Samuel Coffin; Chandana Konduru; Monica Schwarcz; William Frishman |
Related Documents
:
|
9015926 - Study of gastric emptying in patients with pancreatic diabetes (chronic pancreatitis) u... 10372186 - Gastric emptying in patients with type i diabetes mellitus. 6836566 - Disturbances of the alimentary tract motility and hypermotilinemia in the patients with... 1537516 - Sustained slowing effect of lentils on gastric emptying of solids in humans and dogs. 8190526 - Loperamide inhibits the enhanced intestinal glucose absorption of cystic fibrosis in vi... 2366086 - Intrasellar mass with hypopituitarism as a manifestation of sarcoidosis. case report. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Cardiology in review Volume: 17 ISSN: 1538-4683 ISO Abbreviation: Cardiol Rev Publication Date: 2009 Nov-Dec |
Date Detail:
|
Created Date: 2009-10-15 Completed Date: 2010-01-07 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9304686 Medline TA: Cardiol Rev Country: United States |
Other Details:
|
Languages: eng Pagination: 275-9 Citation Subset: IM |
Affiliation:
|
Department of Medicine, Vanderbilt School of Medicine, Vanderbilt Hospital, Nashville, TN, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Bariatric Surgery* Blood Glucose / metabolism Diabetes Mellitus, Type 2 / physiopathology, prevention & control*, surgery* Humans Insulin Resistance / physiology Weight Loss / physiology |
| Chemical | |
Reg. No./Substance:
|
0/Blood Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Triggers and the onset of acute myocardial infarction.
Next Document: Hyperbaric oxygen: its application in cardiology: a historical perspective and personal journey.