Document Detail


Surgical adjuvant immunotherapy for colorectal cancer.
MedLine Citation:
PMID:  732327     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
One hundred forty-four Wistar-Furth rats in 12 therapeutic groups have been studied in a long-term comparison of the effectiveness of nonspecific immunotherapy with MER (methanol extraction residue) vs active-specific immunotherapy with neuraminidase-modified tumor cells. Six months after surgical adjuvant immunotherapy a 100% improvement in survival was achieved with MER immunotherapy compared to untreated control animals. In addition, the use of MER enhanced the value of active-specific immunotherapy where both modalities were combined in sequence. The predicted value of MER-BCG (Bacillus Calmette-Guerin) for the immunotherapy of solid tumors was borne out by these results suggesting that present ongoing clinical trials of MER as adjuvant therapy for large bowel cancer should prove to be successful if properly controlled. The pattern of survival in these experiments suggests that surgical adjuvant immunotherapy is cytostatic rather than cytocidal, and implies the need for long-term, repeated immunizations.
Authors:
W E Enker; J L Jacobitz; K Craft; R W Wissler
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of surgical oncology     Volume:  10     ISSN:  0022-4790     ISO Abbreviation:  J Surg Oncol     Publication Date:  1978  
Date Detail:
Created Date:  1979-03-24     Completed Date:  1979-03-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0222643     Medline TA:  J Surg Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  389-97     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / immunology,  therapy*
Animals
Antigens, Neoplasm / administration & dosage*,  isolation & purification
BCG Vaccine / therapeutic use*
Colonic Neoplasms / immunology,  therapy*
Immunotherapy
Neoplasms, Experimental / therapy
Neuraminidase
Rats
Rats, Inbred WF
Rectal Neoplasms / therapy*
Chemical
Reg. No./Substance:
0/Antigens, Neoplasm; 0/BCG Vaccine; EC 3.2.1.18/Neuraminidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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