| Surgical ablation for atrial fibrillation: the efficacy of a novel bipolar pen device in the cardioplegically arrested and beating heart. | |
| | |
MedLine Citation:
|
PMID: 19026819 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: The introduction of ablation technology has simplified surgical intervention for atrial fibrillation. However, most ablation devices cannot create focal transmural lesions on the beating heart and have difficulty ablating specific regions of the atria, such as the atrioventricular isthmus, coronary sinus, and ganglionated plexus. The purpose of this study was to examine the efficacy of a pen-type bipolar radiofrequency ablation device on both arrested and beating hearts. METHODS: Endocardial and epicardial atrial tissues in the free wall, left atrial roof, atrioventricular annuli, and coronary sinus were ablated for varying time intervals (2.5-15 seconds) in porcine cardioplegically arrested (n = 6) and beating (n = 9) hearts. The hearts were stained with 1% 2,3,5-triphenyl-tetrazolium chloride solution and sectioned to determine lesion depth and width. In 5 animals epicardial fat pads containing ganglionated plexus were stimulated and ablated. RESULTS: Lesion depth increased with ablation time similarly in both arrested and beating hearts. Transmurality was fully achieved in the thin atrial tissue (<4 mm) at 10 seconds in the beating and arrested hearts. The device had a maximal penetration depth of 6.1 mm. Epicardial ablation of the coronary sinus showed complete penetration through the left posterior atrium only in the arrested heart. Seven of 17 fat pads demonstrated a vagal response. All vagal responses were eliminated after ablation. CONCLUSION: The bipolar pen effectively ablated atrial tissue in both arrested and beating hearts. This device might allow the surgeon to ablate tissue in regions not accessible to other devices during atrial fibrillation surgery. |
| | |
Authors:
|
Shun-ichiro Sakamoto; Rochus K Voeller; Spencer J Melby; Shelly C Lall; Nai-lun Chang; Richard B Schuessler; Ralph J Damiano |
Related Documents
:
|
20811539 - Transient global amnesia after ablation of premature ventricular beats arising from the... 11846499 - Catheter ablation and antiarrhythmic drugs for haemodynamically tolerated post-infarcti... 21262079 - A comparison of cardiac post-conditioning and remote pre-conditioning in paediatric car... 2299859 - Transatrial balloon technique for activation mapping during operations for recurrent ve... 12842559 - Left main coronary arterial lesion after microwave epicardial ablation. 8721699 - Contrast cine left ventriculography: comparison of two pigtail catheter shapes and anal... 10955369 - Assessment of coagulation and platelet activation in coronary sinus blood induced by tr... 22153859 - Coronary artery perfusion and myocardial performance after patent ductus arteriosus lig... 14574029 - Advances in devices for cardiac resynchronization in heart failure. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Journal of thoracic and cardiovascular surgery Volume: 136 ISSN: 1097-685X ISO Abbreviation: J. Thorac. Cardiovasc. Surg. Publication Date: 2008 Nov |
Date Detail:
|
Created Date: 2008-11-25 Completed Date: 2008-12-16 Revised Date: 2013-06-04 |
Medline Journal Info:
|
Nlm Unique ID: 0376343 Medline TA: J Thorac Cardiovasc Surg Country: United States |
Other Details:
|
Languages: eng Pagination: 1295-301 Citation Subset: AIM; IM |
Affiliation:
|
Division of Cardiothoracic Surgery, Washington University School of Medicine, Barnes-Jewish Hospital, St. Louis, MO 63110, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Atrial Fibrillation / surgery* Catheter Ablation / instrumentation* Heart Arrest, Induced* Heart Atria / pathology Mitral Valve / pathology Myocardium / pathology Pericardium / pathology Swine Tetrazolium Salts / diagnostic use Tricuspid Valve / pathology |
| Grant Support | |
ID/Acronym/Agency:
|
F32 HL082129-02/HL/NHLBI NIH HHS; R0-1HL032257-21/HL/NHLBI NIH HHS; R01 HL032257/HL/NHLBI NIH HHS; R01 HL032257-25A2/HL/NHLBI NIH HHS; R01 HL032257-28/HL/NHLBI NIH HHS; T32 HL007776/HL/NHLBI NIH HHS; T32 HL007776-15/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Tetrazolium Salts; 298-95-3/neotetrazolium |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Secondary surgical procedures after endovascular stent grafting of the thoracic aorta: successful ap...
Next Document: Harmonic scalpel versus electrocautery for harvest of radial artery conduits: reduced risk of spasm ...