| Surgical Vein Occlusion-Comparison of Four Different Methods in a Rat Model. | |
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MedLine Citation:
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PMID: 21336189 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND:: Among many aspects, wound healing depends on early restoration of venous blood flow across wound margins. The type of surgical occlusion of vein stumps during operations was assumed to have an influence on the early postoperative reunion of vein stumps and thereby on wound healing. Currently, there are different methods of vein stump occlusion available: ligation (e.g., Vicryl), closure using metal clips (e.g., LigaClip), coagulation using manually controlled bipolar forceps, and the use of a computer-controlled bipolar system (e.g., BiClamp). The aim of this study was to surgically and histologically compare the healing process, including new vessel formation after vein occlusion using one of the methods listed. METHODS:: In a rat model (n = 50), both jugular and femoral veins were prepared, occluded twice with one of the methods mentioned above (i.e., 400 occlusions), and finally cut in-between. Groups of 10 animals were reoperated and evaluated surgically and histologically after 5 days, 10 days, 15 days, 30 days, and 90 days. RESULTS:: Occlusion methods using Vicryl, LigaClip, or bipolar forceps allow highly reliable vessel occlusion. Surgical evaluation showed higher occurrence of vessels in between the vein stumps after usage of Vicryl and LigaClip when compared with electrothermic occlusion methods (p = 0.017). Histologic examination showed different courses of the inflammatory reaction and varying capillary counts. Bipolar occlusion methods do cause less vessel occurrence, less inflammatory reaction, and less histologic capillary formation. CONCLUSION:: If a reconnection of the venous flow is desirable, the use of Vicryl and LigaClip might be superior to using electrothermic occlusion methods. In contrast, electrothermic methods cause less new vessel formation as well as less inflammatory reaction. |
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Authors:
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Heinrich M Schubert; Petra Stuetz; Matthias Hohlrieder; Stefan Groesswang; Thomas M Moser; Bernhard Glodny; Johannes Petersen; Heike Haufe; Robert F Zimmermann; Martina Hager |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-17 |
Journal Detail:
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Title: The Journal of trauma Volume: - ISSN: 1529-8809 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376373 Medline TA: J Trauma Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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From the Departments of Plastic and Reconstructive Surgery (H.M.S.), Trauma Surgery and Sports Medicine (P.S., S.G., R.F.Z.), Anaesthesiology and Intensive Care (M.H.), Vascular Surgery (T.M.M.), and Radiology (B.G., J.P.), Medical University of Innsbruck, Innsbruck Austria; and Department of Pathology (H.H., M.H.), Paracelsus Medical University, Salzburg, Austria. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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