Document Detail


Surgical Management of Colorectal Peritoneal Metastases: Treatment and Outcomes Compared with Hepatic Metastases.
MedLine Citation:
PMID:  23138597     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: The liver and peritoneum are common sites of colorectal metastases. Hepatectomy for colorectal liver metastases (CLM) is considered gold standard treatment. We attempt to compare the survival outcomes for CLM patients after hepatectomy to that of patients with colorectal peritoneal metastases (CPM) who underwent cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). METHODS: A retrospective review of patients with CPM and CLM who underwent surgery between January 2003 and May 2011 was performed. The overall (OS) and disease-free survivals (DFS) were compared. RESULTS: There were 22 patients with CPM who underwent CRS and HIPEC and 186 patients who underwent hepatectomy for CLM. Patients with CPM had a 3-year OS of 39 % and DFS of 27.7 %. CLM patients showed a 3-year OS of 58.5 % and a DFS of 28.8 %. Most recurrences for CPM occurred within 2 years, while CLM patients continue to develop systemic recurrences over 3 years, showing a gradual decline in DFS and OS during this period of time. CONCLUSION: Our results show that CRS and HIPEC for CPM confer good OS and DFS rates and that the DFS after CRS and HIPEC is comparable to that after hepatectomy for CLM.
Authors:
Grace Hwei Ching Tan; Melissa Ching Ching Teo; Wallace Chen; Ser Yee Lee; Deanna Wan Jie Ng; Chee Kian Tham; Khee Chee Soo
Related Documents :
24866437 - Is resection or transplantation the ideal treatment in patients with hepatocellular car...
791477 - Cyclophosphamide, vincristine and procarbazine in the treatment of malignant melanoma.
23585667 - Immunohistochemical characteristics of hepatocellular carcinoma in non-cirrhotic livers.
23634197 - Systemic treatment of liver metastases from colorectal cancer.
12168947 - Neutropenic infections add significant costs to palliative chemotherapy in breast cancer.
14581337 - Pharmacokinetic study of cisplatin and infusional etoposide phosphate in advanced breas...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-9
Journal Detail:
Title:  Journal of gastrointestinal cancer     Volume:  -     ISSN:  1941-6636     ISO Abbreviation:  J Gastrointest Cancer     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101479627     Medline TA:  J Gastrointest Cancer     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of General Surgery, Singapore General Hospital, 9 Hospital Drive, Singapore, 169612, Singapore.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Chemopreventive Effects of Selenium on Cancer Marker Indices and Ultrastructural Changes During 1,2 ...
Next Document:  A new self-expandable aortic valved stent deployed above native leaflets for aortic insufficiency: a...