Document Detail


Surgical excision and immediate postoperative radiotherapy versus cryotherapy and intralesional steroids in the management of keloids: a prospective clinical trial.
MedLine Citation:
PMID:  20639666     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To compare the efficacy and tolerability of surgical excision and radiotherapy with those of cryotherapy and intralesional steroid treatment of keloids. SUBJECTS AND METHODS: Twenty-six patients with a total of 76 keloids were enrolled in this study. Nineteen patients with 44 keloids underwent surgical excision combined with immediate 12-Gy irradiation (group A) while the remaining 9 patients with 32 keloids received multiple sessions of intralesional steroid treatment after cryotherapy which continued until flattening of lesion(s) occurred (group B). Two patients were included in both treatment groups. All patients were followed up at regular intervals for at least 1 year. RESULTS: In both treatment groups, keloids responded well without any major side effect. While patients of group A were all satisfied, those of group B (with a mean number of treatment sessions of 5.84 +/- 2.51) experienced more side effects, a more prolonged course, a higher recurrence rate and less satisfaction. CONCLUSION: This study showed that surgery plus immediate postoperative irradiation was an effective and relatively safe choice for treatment of keloids. Although cryotherapy combined with intralesional steroids was associated with more side effects and higher relapse rates, it could be a good choice for small and newly formed keloids.
Authors:
Maryam Emad; Shapour Omidvari; Ladan Dastgheib; Afshin Mortazavi; Haleh Ghaem
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article     Date:  2010-07-14
Journal Detail:
Title:  Medical principles and practice : international journal of the Kuwait University, Health Science Centre     Volume:  19     ISSN:  1423-0151     ISO Abbreviation:  Med Princ Pract     Publication Date:  2010  
Date Detail:
Created Date:  2010-07-19     Completed Date:  2010-10-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8901334     Medline TA:  Med Princ Pract     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  402-5     Citation Subset:  IM    
Copyright Information:
Copyright 2010 S. Karger AG, Basel.
Affiliation:
Department of Dermatology, Shiraz University of Medical Sciences, Shiraz, Iran.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Cryotherapy
Female
Glucocorticoids / therapeutic use
Humans
Injections, Intralesional
Keloid / radiotherapy,  surgery,  therapy*
Male
Middle Aged
Patient Satisfaction
Postoperative Period
Prospective Studies
Radiotherapy, Adjuvant
Recurrence
Young Adult
Chemical
Reg. No./Substance:
0/Glucocorticoids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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