Document Detail

Surgery and postoperative mebendazole in the treatment of hydatid disease.
MedLine Citation:
PMID:  12070583     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Surgery was virtually the only curative method for hydatid disease until the early 1970s when studies have shown the safety and effectiveness of benzomidazole compounds for the treatment of hydatid cysts. Our aim is to establish the outcome of chemotherapy in the postoperative period on secondary hydatid cyst. METHODS: Between 1987 to 1996 inclusive, all patients who were diagnosed with hepatic hydatid disease and who underwent surgery and received a post operative course of chemotherapy at Princess Basma Teaching Hospital, Irbid, North Jordan, were retrospectively reviewed with special referral to side effects of chemotherapy and recurrence rate of hydatid disease. RESULTS: There were 78 patients (41 females, 37 males). All age groups were involved with an age range of 8-70 years. The main clinical presentation was upper abdominal discomfort, heaviness and mild pain. Ultrasonography and indirect hemagglutination test diagnosed more than 90% of cases. All patients were operated upon and received a postoperative prophylactic course of mebendazole. We reported a recurrence rate of less than 3%. Excessive loss of hair as a side effect to mebendazole therapy occurred in 2 young female patients. CONCLUSION: The postoperative prophylactic course of mebendazole is reliable, safe and with minor side effects and the recurrence rate of the disease was reduced to the lowest possible levels.
Fuad F Ammari; Abdel K Omari
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Saudi medical journal     Volume:  23     ISSN:  0379-5284     ISO Abbreviation:  Saudi Med J     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-06-18     Completed Date:  2002-07-23     Revised Date:  2008-06-23    
Medline Journal Info:
Nlm Unique ID:  7909441     Medline TA:  Saudi Med J     Country:  Saudi Arabia    
Other Details:
Languages:  eng     Pagination:  568-71     Citation Subset:  IM    
Department of General Surgery, Faculty of Medicine, Jordan University of Science and Technology, PO Box 3030, Irbid 22110, Jordan.
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MeSH Terms
Antinematodal Agents / administration & dosage*
Combined Modality Therapy
Developing Countries
Echinococcosis, Hepatic / diagnosis,  drug therapy*,  surgery*
Follow-Up Studies
Hospitals, Teaching
Mebendazole / administration & dosage*
Middle Aged
Postoperative Care
Preoperative Care
Retrospective Studies
Risk Assessment
Treatment Outcome
Reg. No./Substance:
0/Antinematodal Agents; 31431-39-7/Mebendazole
Comment In:
Saudi Med J. 2002 Nov;23(11):1425; author reply 1425   [PMID:  12506313 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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