Document Detail

Surgery in congenital hyperinsulinism-tips and tricks not only for surgeons. A practical guide.
MedLine Citation:
PMID:  21186007     Owner:  NLM     Status:  In-Process    
Each form of congenital hyperinsulinism (CHI)-focal, diffuse, atypical-requires its own surgical strategy and technique. Focal CHI is treated by a positron emission tomography/computed tomography-guided, local resection which is confined only to the lesion. As much healthy pancreatic tissue as possible is preserved. On the contrary, the therapeutic mainstay of diffuse CHI must be conservative nowadays. Only in the exceptional cases in which medical treatment fails surgical therapy is warranted to prevent hypoglycemia. However, the extension of resection that is able to cure hyperinsulinism while avoiding diabetes is not known today. The outcome, therefore, is unpredictable. In the rare atypical cases it is important to stop the resection at the right time in order not to finish unnecessarily with a mutilating operation.
Winfried Barthlen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Seminars in pediatric surgery     Volume:  20     ISSN:  1532-9453     ISO Abbreviation:  Semin. Pediatr. Surg.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2010-12-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9216162     Medline TA:  Semin Pediatr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  56-9     Citation Subset:  IM    
Copyright Information:
2011 Elsevier Inc. All rights reserved.
Clinic for Pediatric Surgery, University of Greifwald, Germany.
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