| Surfactant treatment in premature infants with Respiratory Distress Syndrome in Curaçao. | |
| | |
MedLine Citation:
|
PMID: 11677907 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Surfactant replacement therapy for Respiratory Distress Syndrome (RDS) in premature neonates has been established as an effective treatment, although significant mortality and morbidity remain. In Curaçao, surfactant became available as a therapeutic option in 1994. A retrospective cohort study was performed to describe the results of surfactant treatment in premature newborns with RDS in Curaçao between 1994 and 1998. Of 429 infants admitted to the study hospital in this period, 7.5% (n = 32) developed RDS and were treated with surfactant. Twenty-five per cent (n = 8) of these infants died, most of them in the first year of surfactant treatment. Twenty-eight per cent (n = 9) developed bronchopulmonary dysplasia (BPD), the most frequently observed complication. The highest incidence of BPD (44%) was found in the very low birth weight infants (750-1500 g); all infants with BPD were 27-30 weeks of gestational age. The duration of ventilator dependence was significantly associated with the development of BPD (p < 0.05). No other risk factors for complications during the treatment course could be identified. The mean time between birth and the first surfactant treatment was more than nine hours. In this study, we found low incidence rates of RDS and BPD, and a considerable mortality in surfactant treated newborns. This pilot study shows that surfactant treatment of premature infants is feasible in Curaçao. Earlier administration of surfactant, preferably within 2-3 hours after birth, is expected to lower the risk of death and oxygen dependence. |
| | |
Authors:
|
A A Verhagen; S O Keli; G N van der Meulen; H Wiersma; M Arias; I R Angelista; F D Muskiet |
Related Documents
:
|
21245927 - Rapid recovery of fat mass in small for gestational age preterm infants after term. 3442537 - Cellular defense of the avian respiratory system. influx of phagocytes: elicitation ver... 12854377 - Exogenous surfactant therapy in newborn infants. 1346877 - Respiratory disease in very-low-birthweight infants after prenatal thyrotropin-releasin... 3803267 - Unmarried at delivery. ii. perinatal morbidity and mortality. 19937747 - Change in imitation for object manipulation between 10 and 12 months of age. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The West Indian medical journal Volume: 50 ISSN: 0043-3144 ISO Abbreviation: West Indian Med J Publication Date: 2001 Jun |
Date Detail:
|
Created Date: 2001-10-25 Completed Date: 2001-12-04 Revised Date: 2008-03-10 |
Medline Journal Info:
|
Nlm Unique ID: 0417410 Medline TA: West Indian Med J Country: Jamaica |
Other Details:
|
Languages: eng Pagination: 117-22 Citation Subset: IM |
Affiliation:
|
St Elisabeth Hospital, Departments of Paediatrics and Clinical Epidemiology and Biostatistics, Curaçao, Netherlands Antilles. e.verhagen@bkk.azg.nl |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Bronchopulmonary Dysplasia
/
epidemiology Cohort Studies Female Humans Incidence Infant, Newborn Male Netherlands Antilles / epidemiology Pilot Projects Pulmonary Surfactants / therapeutic use* Respiratory Distress Syndrome, Newborn / epidemiology, therapy* Retrospective Studies Risk Factors |
| Chemical | |
Reg. No./Substance:
|
0/Pulmonary Surfactants |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Understanding the mechanism of action of cytochrome c oxidase in normal and disease states: shark he...
Next Document: Age-specific incidence of cancer in Kingston and St Andrew, Jamaica, 1993-1997.