Document Detail


Surfactant proteins A and D in pregnancy and parturition.
MedLine Citation:
PMID:  21196309     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Surfactant proteins A and D have extra-pulmonary expression at various mucosal sites including the reproductive tract. Reproductive tissues require a fine immune balance, strong enough to keep infection at a bay and at the same time, subtle enough to support an allogeneic fetus throughout the pregnancy. Roles of SP-A and SP-D have been studied in depth and include immunoregulatory function, besides strengthening the innate immune system against various pathogens in the lungs. Interestingly, levels of SP-A and SP-D in the amniotic fluid increase progressively in pregnancy. SP-A has been implicated in the induction of parturition. The present review elaborates the plausible roles of SP-A and SP-D in pregnancy maintenance and future applications.
Authors:
Ajit Kumar Yadav; Taruna Madan; Andres Lopez Bernal
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-01-01
Journal Detail:
Title:  Frontiers in bioscience (Elite edition)     Volume:  3     ISSN:  1945-0508     ISO Abbreviation:  Front Biosci (Elite Ed)     Publication Date:  2011  
Date Detail:
Created Date:  2011-01-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101485240     Medline TA:  Front Biosci (Elite Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  291-300     Citation Subset:  IM    
Affiliation:
National Institute for Research in Reproductive Health, Mumbai, India.
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MeSH Terms
Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
//Wellcome Trust

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