| Surfactant proteins B and C are both necessary for alveolar stability at end expiration in premature rabbits with respiratory distress syndrome. | |
| | |
MedLine Citation:
|
PMID: 18276900 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Modified natural surfactant preparations, used for treatment of respiratory distress syndrome in premature infants, contain phospholipids and the hydrophobic surfactant protein (SP)-B and SP-C. Herein, the individual and combined effects of SP-B and SP-C were evaluated in premature rabbit fetuses treated with airway instillation of surfactant and ventilated without positive end-expiratory pressure. Artificial surfactant preparations composed of synthetic phospholipids mixed with either 2% (wt/wt) of porcine SP-B, SP-C, or a synthetic poly-Leu analog of SP-C (SP-C33) did not stabilize the alveoli at the end of expiration, as measured by low lung gas volumes of approximately 5 ml/kg after 30 min of ventilation. However, treatment with phospholipids containing both SP-B and SP-C/SP-C33 approximately doubled lung gas volumes. Doubling the SP-C33 content did not affect lung gas volumes. The tidal volumes were similar in all groups receiving surfactant. This shows that SP-B and SP-C exert different physiological effects, since both proteins are needed to establish alveolar stability at end expiration in this animal model of respiratory distress syndrome, and that an optimal synthetic surfactant probably requires the presence of mimics of both SP-B and SP-C. |
| | |
Authors:
|
Andreas Almlén; Guido Stichtenoth; Bim Linderholm; Marie Haegerstrand-Björkman; Bengt Robertson; Jan Johansson; Tore Curstedt |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-02-14 |
Journal Detail:
|
Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 104 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2008 Apr |
Date Detail:
|
Created Date: 2008-04-03 Completed Date: 2008-06-17 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
|
Languages: eng Pagination: 1101-8 Citation Subset: IM |
Affiliation:
|
Dept. of Molecular Medicine and Surgery, Section of Clinical Chemistry, Bldg. L2:03, Karolinska Univ. Hospital, SE-171 76 Stockholm, Sweden. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
1,2-Dipalmitoylphosphatidylcholine
/
pharmacology Amino Acid Sequence Animals Animals, Newborn / physiology* Female Humans Infant, Newborn Lung Volume Measurements Molecular Sequence Data Phospholipids / metabolism Positive-Pressure Respiration Pregnancy Pulmonary Alveoli / physiology* Pulmonary Surfactant-Associated Protein B / physiology* Pulmonary Surfactant-Associated Protein C / physiology* Pulmonary Surfactants / pharmacology Rabbits Respiratory Distress Syndrome, Newborn / physiopathology* Respiratory Mechanics / physiology Tidal Volume / physiology |
| Chemical | |
Reg. No./Substance:
|
0/Phospholipids; 0/Pulmonary Surfactant-Associated Protein B; 0/Pulmonary Surfactant-Associated Protein C; 0/Pulmonary Surfactants; 2644-64-6/1,2-Dipalmitoylphosphatidylcholine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The effect of conductive ventilation heterogeneity on diffusing capacity measurement.
Next Document: Neutrophil accumulation following passive stretches contributes to adaptations that reduce contracti...