Document Detail


Surfactant protein-B and lung function in surfactant-treated preterm lambs.
MedLine Citation:
PMID:  9167854     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We asked if the amount of SP-B (range 37-410 micrograms/ml) in surfactants used to treat preterm lambs at 123 days of gestation correlated with postnatal lung function or the SP-B content of surfactant recovered by alveolar washes after 10 h ventilation. Ventilation was initiated using a low tidal volume strategy to minimize early lung injury. There were small increases in compliance for the lambs treated with surfactants containing more than 37 micrograms/ml SP-B and an increased lung volume for lambs treated with a surfactant containing 385 micrograms/ml/ml relative to the surfactant containing 37 micrograms/ml SP-B. The amount of SP-B in the surfactant used for treatment correlated linearly with the amount of SP-B in the surfactant recovered from the lambs (r = 0.95, p < 0.001). Albumin leak from the vasculature to the airspace was low as was total protein in alveolar washes, indicating minimal lung injury. The SP-B content of surfactant (from 37 to 410 micrograms/ml) had minimal effects on postnatal lung function over a 10-hour study period in lambs ventilated in a manner to minimize lung injury.
Authors:
C M Rebello; M Ikegami; R E Hernandez; A H Jobe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biology of the neonate     Volume:  71     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1997  
Date Detail:
Created Date:  1997-07-22     Completed Date:  1997-07-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  327-36     Citation Subset:  IM    
Affiliation:
Harbor-UCLA Medical Center, Department of Pediatrics, Torrance, USA.
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MeSH Terms
Descriptor/Qualifier:
Biological Products*
Bronchoalveolar Lavage Fluid / chemistry*
Female
Humans
Infant, Newborn
Lung / drug effects,  physiology*
Pregnancy
Proteolipids / analysis*
Pulmonary Surfactants / analysis*,  chemistry,  therapeutic use*
Respiratory Insufficiency / drug therapy,  veterinary*
Respiratory Mechanics / drug effects*
Grant Support
ID/Acronym/Agency:
HD-12714/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Biological Products; 0/Proteolipids; 0/Pulmonary Surfactants; 108778-82-1/beractant

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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