Document Detail

Surfactant lecithin fatty acid composition and its relationship to the infantile respiratory distress syndrome.
MedLine Citation:
PMID:  580959     Owner:  NLM     Status:  MEDLINE    
In order to evaluate the role of surfactant lecithin composition in the development of the infantile respiratory distress syndrome (IRDS) we have examined lecithin fatty acid composition from gastric aspirates obtained at the time of delivery from 14 full term healthy infants, 9 control premature infants without respiratory distress, and 16 premature infants who developed IRDS. The latter had significantly reduced concentrations of palmitic acid (48.4 +/- 1.8% vs. 65.3 +/- 1.5% in fullterm and 59.5 +/- 0.8% in control premature infants, P less than 0.001). None of the infants in whom palmitic acid was more than 60% of total lecithin fatty acids developed IRDS, whereas 10 of 11 infants with values below 50% did develop this complication. Lecithin from gastric aspirate was shown to be similar in fatty acid composition to lecithins from tracheal washings and amniotic fluid. Palmitic acid concentrations in lecithins of serial tracheal washings paralleled the clinical course of eight infants with IRDS.
J A Balint; E C Kyriakides; G D Gunawardhane; H Risenberg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric research     Volume:  12     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1978 Jun 
Date Detail:
Created Date:  1978-09-15     Completed Date:  1978-09-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  715-9     Citation Subset:  IM    
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MeSH Terms
Fatty Acids / analysis*
Gastric Juice / analysis*
Infant, Newborn
Palmitic Acids / analysis
Phosphatidylcholines / analysis
Pulmonary Surfactants / analysis*
Respiratory Distress Syndrome, Newborn / metabolism*
Reg. No./Substance:
0/Fatty Acids; 0/Palmitic Acids; 0/Phosphatidylcholines; 0/Pulmonary Surfactants

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