Document Detail

Surfactant increases the uniformity of lung aeration at birth in ventilated preterm rabbits.
MedLine Citation:
PMID:  21451432     Owner:  NLM     Status:  MEDLINE    
Surfactant deficiency is a major cause of respiratory failure in newborns. We have investigated the roles of surfactant and positive end-expiratory pressure (PEEP) in the development of a functional residual capacity (FRC) and the distribution of ventilation at birth. Preterm rabbit pups (28 d GA) were delivered and received either saline or surfactant and then ventilated with (3PEEP) or without (0PEEP) 3 cm H2O PEEP (groups: saline/0PEEP, surfactant/0PEEP, saline/3PEEP, surfactant/3PEEP). Lung gas volumes were measured using plethysmography, and the uniformity of ventilation was analyzed using phase contrast (PC) x-ray imaging. Surfactant/0PEEP pups had greater FRCs and the lungs were more uniformly ventilated than saline/0PEEP pups; FRC at inflation 19-21 was 2.46 ± 0.52 mL/kg versus 0.91 ± 0.95 mL/kg (p < 0.05). Saline/3PEEP pups developed an FRC of 7.54 ± 1.68 mL/kg at inflation 19-21 (p < 0.05), but the distribution of ventilation was initially nonuniform. Surfactant/3PEEP pups had an FRC of 8.50 ± 0.80 mL/kg (at inflation 19-21), and the distribution of ventilation was more uniform than with saline/3PEEP (p < 0.05). In ventilated preterm newborn rabbits, PEEP has a greater effect on FRC than surfactant, although the two are additive. Surfactant, administered at birth, markedly improved the uniformity of ventilation irrespective of whether PEEP was applied.
Melissa L Siew; Arjan B Te Pas; Megan J Wallace; Marcus J Kitchen; M Sirajul Islam; Robert A Lewis; Andreas Fouras; Colin J Morley; Peter G Davis; Naoto Yagi; Kentaro Uesugi; Stuart B Hooper
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media    
Journal Detail:
Title:  Pediatric research     Volume:  70     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-09     Completed Date:  2011-10-07     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  50-5     Citation Subset:  IM    
Monash Institute of Medical Research, Clayton, Vic 3168, Australia.
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MeSH Terms
Animals, Newborn
Biological Agents / pharmacology*
Functional Residual Capacity / drug effects
Gestational Age
Lung / drug effects*,  radiography
Lung Compliance / drug effects
Phospholipids / pharmacology*
Positive-Pressure Respiration*
Premature Birth*
Pulmonary Surfactants / pharmacology*
Pulmonary Ventilation / drug effects*
Respiratory Mechanics / drug effects
Reg. No./Substance:
0/Biological Agents; 0/Phospholipids; 0/Pulmonary Surfactants; KE3U2023NP/poractant alfa

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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