| Surfactant function affected by airway inflammation and cooling: possible impact on exercise-induced asthma. | |
| | |
MedLine Citation:
|
PMID: 10759448 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Pulmonary surfactant maintains patency of narrow conducting airways. An inflammation, with a leakage of plasma proteins into the airway lumen, causes surfactant to lose some of this ability. Will a lowering of temperature aggravate the deteriorating effect of an inflammation? Calf lung surfactant extract (CLSE) with proteins added was studied with a capillary surfactometer (CS) at temperatures of 25-42 degrees C. BALB/c mice were infected with respiratory syncytial virus (RSV). Six days later the lungs were lavaged and the surfactant in the lavage fluid was studied with the CS at temperatures of 25-42 degrees C. Lavage fluid from allergen challenged asthmatics was examined for its content of surfactant inhibitors at reduced temperatures. It was shown that CLSE with proteins gradually lost its ability to maintain patency as the temperature was lowered. Lavage fluid from the RSV infected mice showed a similar dysfunction at low temperatures. Lavage fluid from the airways of human asthmatics, when challenged with antigen but not with saline, contained agents inhibiting surface activity, particularly at reduced temperatures. Airway inflammation causes surfactant to lose its ability to maintain patency, particularly as the temperature is reduced. That might be a reason for the increased airway resistance observed in asthma patients hyperventilating in cold weather. |
| | |
Authors:
|
G Enhorning; J Hohlfeld; N Krug; G Lema; R C Welliver |
Related Documents
:
|
17439278 - Ph-dependent phase behavior of carbohydrate-based gemini surfactants. the effects of ca... 15773118 - Electrochemical instability in the transfer of cationic surfactant across the 1,2-dichl... 14516088 - Simultaneous determination of cationic surfactants and nonionic surfactants by ion-asso... 23528608 - Probing the interaction of oppositely charged gold nanoparticles with dppg and dppc lan... 14970228 - As(iii) and sb(iii) uptake by glpf and efflux by arsb in escherichia coli. 7791498 - Laser-induced release of liposome-encapsulated dye to monitor tissue temperature: a pre... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The European respiratory journal Volume: 15 ISSN: 0903-1936 ISO Abbreviation: Eur. Respir. J. Publication Date: 2000 Mar |
Date Detail:
|
Created Date: 2000-05-25 Completed Date: 2000-05-25 Revised Date: 2013-05-23 |
Medline Journal Info:
|
Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: DENMARK |
Other Details:
|
Languages: eng Pagination: 532-8 Citation Subset: IM |
Affiliation:
|
Dept of Gynecology/Obstetrics, State University of New York at Buffalo, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Albumins Animals Asthma, Exercise-Induced / physiopathology* Cattle Cold Temperature Fibrinogen Humans Male Mice Mice, Inbred BALB C Pulmonary Surfactants / physiology* |
| Grant Support | |
ID/Acronym/Agency:
|
HL-49971/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Albumins; 0/Pulmonary Surfactants; 9001-32-5/Fibrinogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Preservation of intraalveolar surfactant in a rat lung ischaemia/reperfusion injury model.
Next Document: Sniff nasal inspiratory pressure as a marker of respiratory function in motor neuron disease.