Document Detail

Surfactant bolus instillation: effects of different doses on blood pressure and cerebral blood flow velocities.
MedLine Citation:
PMID:  7948436     Owner:  NLM     Status:  MEDLINE    
Fifteen preterm infants suffering from respiratory distress syndrome were randomly allocated to receive either high-dose (200 mg/kg) or low-dose (100 mg/kg) surfactant treatment. Retreatments were done with the low dose. Blood pressure, blood gases and cerebral blood flow velocities were determined before and after 24 bolus instillations. With the high dose mean blood pressure and mean cerebral blood flow velocity dropped significantly. With the low dose only mean cerebral blood flow velocity decreased; the course was unrelated to blood pressure or PCO2 fluctuations. The mechanisms leading to the observed circulatory changes after surfactant instillation remain unclear.
M Rey; H Segerer; C Kiessling; M Obladen
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biology of the neonate     Volume:  66     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1994  
Date Detail:
Created Date:  1994-12-02     Completed Date:  1994-12-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  16-21     Citation Subset:  IM    
Abteilung Neonatalogie, Universitätsklinikum Rudolf Virchow, Freie Universität Berlin, Deutschland.
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MeSH Terms
Blood Flow Velocity / drug effects
Blood Pressure / drug effects*
Cerebrovascular Circulation / drug effects*
Dose-Response Relationship, Drug
Infant, Newborn
Pulmonary Surfactants / administration & dosage*,  adverse effects*,  therapeutic use
Respiratory Distress Syndrome, Newborn / drug therapy*
Reg. No./Substance:
0/Pulmonary Surfactants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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