Document Detail

Surfactant alterations following acute bleomycin and hyperoxia-induced lung damage.
MedLine Citation:
PMID:  2430349     Owner:  NLM     Status:  MEDLINE    
Hamsters treated with 0.5 U/kg intratracheal bleomycin and exposed for 24 h to 80% O2 develop acute respiratory failure 72 h after treatment. To examine indirectly the lung epithelial type II cell changes, alterations in pulmonary surfactant was measured. Presence and amount of dipalmitoyl phosphatidyl choline (DDPC) and sphingomyelin (SM) were measured, and the DPPC/SM ratio was determined in brochoalveolar lavage samples from treated and control animals 24, 48, 72, and 96 h after treatment. Hamsters treated with bleomycin and O2 had a significantly decreased DPPC/SM ratio at 72 h, which is the time of onset of respiratory failure. The decreased DPPC/SM ratio may reflect type II cell damage and inhibition of surfactant function by the edema fluid.
M E Goad; A F Tryka; H P Witschi
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Toxicology letters     Volume:  32     ISSN:  0378-4274     ISO Abbreviation:  Toxicol. Lett.     Publication Date:  1986 Sep 
Date Detail:
Created Date:  1986-11-26     Completed Date:  1986-11-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7709027     Medline TA:  Toxicol Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  173-8     Citation Subset:  IM; S    
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MeSH Terms
1,2-Dipalmitoylphosphatidylcholine / analysis*
Bleomycin / toxicity*
Chromatography, High Pressure Liquid
Oxygen / toxicity*
Respiratory Insufficiency / chemically induced*,  pathology
Sphingomyelins / analysis
Reg. No./Substance:
0/Sphingomyelins; 11056-06-7/Bleomycin; 2644-64-6/1,2-Dipalmitoylphosphatidylcholine; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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