Document Detail


Surfactant alterations following acute bleomycin and hyperoxia-induced lung damage.
MedLine Citation:
PMID:  2430349     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hamsters treated with 0.5 U/kg intratracheal bleomycin and exposed for 24 h to 80% O2 develop acute respiratory failure 72 h after treatment. To examine indirectly the lung epithelial type II cell changes, alterations in pulmonary surfactant was measured. Presence and amount of dipalmitoyl phosphatidyl choline (DDPC) and sphingomyelin (SM) were measured, and the DPPC/SM ratio was determined in brochoalveolar lavage samples from treated and control animals 24, 48, 72, and 96 h after treatment. Hamsters treated with bleomycin and O2 had a significantly decreased DPPC/SM ratio at 72 h, which is the time of onset of respiratory failure. The decreased DPPC/SM ratio may reflect type II cell damage and inhibition of surfactant function by the edema fluid.
Authors:
M E Goad; A F Tryka; H P Witschi
Related Documents :
16770069 - Mechanisms to explain surfactant responses.
12236559 - The impact of respiratory syncytial virus infection: a prospective study in hospitalize...
9473819 - Exogenous surfactant therapy for neonatal respiratory distress syndrome: a two-year cli...
24145619 - Early-life factors associated with pediatric functional constipation: an italian multic...
8819619 - Surfactant and respiratory distress syndrome.
19129059 - X-linked myotubular myopathy with a novel mtm1 mutation in a taiwanese child.
21218679 - Effectiveness of cheek and jaw support to improve feeding performance of preterm infants.
3400899 - Significance of ige level in amniotic fluid and cord blood for the prediction of allergy.
1476419 - Abo segregation distortion in visakhapatnam, india.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Toxicology letters     Volume:  32     ISSN:  0378-4274     ISO Abbreviation:  Toxicol. Lett.     Publication Date:  1986 Sep 
Date Detail:
Created Date:  1986-11-26     Completed Date:  1986-11-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7709027     Medline TA:  Toxicol Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  173-8     Citation Subset:  IM; S    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
1,2-Dipalmitoylphosphatidylcholine / analysis*
Animals
Bleomycin / toxicity*
Chromatography, High Pressure Liquid
Cricetinae
Male
Mesocricetus
Oxygen / toxicity*
Respiratory Insufficiency / chemically induced*,  pathology
Sphingomyelins / analysis
Chemical
Reg. No./Substance:
0/Sphingomyelins; 11056-06-7/Bleomycin; 2644-64-6/1,2-Dipalmitoylphosphatidylcholine; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Blockage of resting potassium conductance in frog muscle fibers by a toxin isolated from the sponge ...
Next Document:  Health surveillance and biological monitoring of pesticide formulators in India.