Document Detail


Surfactant administration for neonatal respiratory distress does not improve lung interstitial fluid clearance: echographic and experimental evidence.
MedLine Citation:
PMID:  20629494     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Recent ultrasonographic studies suggest that the administration of surfactant to preterm infants with respiratory distress syndrome (RDS) does not affect lung water clearance. The purpose of the study was also to look at clearance of lung water in preterm rabbits receiving surfactant.
METHODS: Lung ultrasound was performed in 73 neonates at different gestational ages (range 23-34 weeks) with radiological and clinical signs of RDS, before and after surfactant administration. In premature rabbits (28-29 days' gestational age), either receiving or not receiving surfactant, we followed the time course of lung water balance considering the wet weight/dry weight ratio, the morphology and compliance of alveoli and pulmonary interstitial pressure.
RESULTS: In all RDS infants lung ultrasound images consistently showed a generalized increase in extravascular lung fluid which remained unchanged after surfactant administration and did not affect the rate of fluid clearance. Surfactant administration in premature rabbits did not improve the time course of lung fluid clearance.
CONCLUSIONS: Data from ultrasound in preterm babies are confirmed by animal experiments.
Authors:
Luigi Cattarossi; Roberto Copetti; Besa Poskurica; Giuseppe Miserocchi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  38     ISSN:  1619-3997     ISO Abbreviation:  J Perinat Med     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-03     Completed Date:  2011-01-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  557-63     Citation Subset:  IM    
Affiliation:
Departments of Paediatrics and Emergency Medicine, San Antonio Abate Hospital, Tolmezzo, Italy. luigi.cattarossi@ass3.sanita.fvg.it
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Disease Models, Animal
Extracellular Fluid / physiology
Humans
Infant, Newborn
Infant, Premature
Lung / drug effects*,  physiopathology*,  ultrasonography
Pulmonary Gas Exchange / drug effects,  physiology
Pulmonary Surfactants / administration & dosage*
Rabbits
Respiratory Distress Syndrome, Newborn / drug therapy*,  physiopathology,  ultrasonography
Water-Electrolyte Balance / drug effects,  physiology
Chemical
Reg. No./Substance:
0/Pulmonary Surfactants

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