Document Detail


Surfactant administration by transient intubation in infants 29 to 35 weeks' gestation with respiratory distress syndrome decreases the likelihood of later mechanical ventilation: a randomized controlled trial.
MedLine Citation:
PMID:  16163369     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE:To assess, among premature infants with early respiratory distress syndrome (RDS), the effect of one dose of intratracheally administered surfactant followed by extubation to nasal continuous positive airway pressure (NCPAP) on subsequent mechanical ventilation (MV), when compared with NCPAP alone. STUDY DESIGN:Randomized, blinded trial in infants 29 to 35 weeks' gestation with mild-to-moderate RDS requiring supplemental oxygen and NCPAP. Infants were randomized to intubation, surfactant treatment, and immediate extubation (surfactant group N=52), or to no intervention (control group N=53). All infants were subsequently managed with NCPAP. RESULTS:Need for later MV was 70% in the control group and 50% in the surfactant group. Surfactant group subjects had lower inspired oxygen fraction (FiO(2)) after study intervention and were less likely to require subsequent surfactant. Overall surfactant use, duration of O(2) therapy, length of stay, and bronchopulmonary dysplasia were unaffected. CONCLUSION:Among premature infants with mild-to-moderate RDS, transient intubation for surfactant administration reduces later MV.
Authors:
Ann Reininger; Rubia Khalak; James W Kendig; Rita M Ryan; Timothy P Stevens; Linda Reubens; Carl T D'Angio
Related Documents :
23582959 - Progress in understanding the pathogenesis of bpd using the baboon and sheep models.
23151209 - Development of pbpk models for pfoa and pfos for human pregnancy and lactation life sta...
23414429 - The impact of preterm birth and bronchopulmonary dysplasia on the developing lung: long...
12236559 - The impact of respiratory syncytial virus infection: a prospective study in hospitalize...
8333929 - Corticosteroids and surfactant for prevention of neonatal rds.
23459869 - Not like me = bad: infants prefer those who harm dissimilar others.
20863419 - Bifidobacterium animalis subsp. lactis bb-12 in reducing the risk of infections in infa...
19070449 - Usefulness of the whole-blood interferon-gamma release assay for diagnosis of extrapulm...
19357239 - Relation of schizophrenia prevalence to latitude, climate, fish consumption, infant mor...
Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  25     ISSN:  0743-8346     ISO Abbreviation:  J Perinatol     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-27     Completed Date:  2006-01-17     Revised Date:  2010-03-23    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  703-8     Citation Subset:  IM    
Copyright Information:
Journal of Perinatology (2005) 25, 703-708. doi:10.1038/sj.jp.7211381; published online 15 September 2005.
Affiliation:
Strong Children's Research Center, University of Rochester, Rochester, NY 14642, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Biological Products / administration & dosage*
Continuous Positive Airway Pressure
Female
Humans
Infant, Newborn
Male
Respiration, Artificial*
Respiratory Distress Syndrome, Newborn / drug therapy*
Time Factors
Chemical
Reg. No./Substance:
0/Biological Products; 108778-82-1/beractant

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Validity of hospital discharge data for identifying infants with cardiac defects.
Next Document:  Intracavernosal prostaglandin E1 self vs office injection therapy in patients with erectile dysfunct...