Document Detail

Surfactant administration by transient intubation in infants 29 to 35 weeks' gestation with respiratory distress syndrome decreases the likelihood of later mechanical ventilation: a randomized controlled trial.
MedLine Citation:
PMID:  16163369     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE:To assess, among premature infants with early respiratory distress syndrome (RDS), the effect of one dose of intratracheally administered surfactant followed by extubation to nasal continuous positive airway pressure (NCPAP) on subsequent mechanical ventilation (MV), when compared with NCPAP alone. STUDY DESIGN:Randomized, blinded trial in infants 29 to 35 weeks' gestation with mild-to-moderate RDS requiring supplemental oxygen and NCPAP. Infants were randomized to intubation, surfactant treatment, and immediate extubation (surfactant group N=52), or to no intervention (control group N=53). All infants were subsequently managed with NCPAP. RESULTS:Need for later MV was 70% in the control group and 50% in the surfactant group. Surfactant group subjects had lower inspired oxygen fraction (FiO(2)) after study intervention and were less likely to require subsequent surfactant. Overall surfactant use, duration of O(2) therapy, length of stay, and bronchopulmonary dysplasia were unaffected. CONCLUSION:Among premature infants with mild-to-moderate RDS, transient intubation for surfactant administration reduces later MV.
Ann Reininger; Rubia Khalak; James W Kendig; Rita M Ryan; Timothy P Stevens; Linda Reubens; Carl T D'Angio
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  25     ISSN:  0743-8346     ISO Abbreviation:  J Perinatol     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-27     Completed Date:  2006-01-17     Revised Date:  2010-03-23    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  703-8     Citation Subset:  IM    
Copyright Information:
Journal of Perinatology (2005) 25, 703-708. doi:10.1038/; published online 15 September 2005.
Strong Children's Research Center, University of Rochester, Rochester, NY 14642, USA.
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MeSH Terms
Biological Products / administration & dosage*
Continuous Positive Airway Pressure
Infant, Newborn
Respiration, Artificial*
Respiratory Distress Syndrome, Newborn / drug therapy*
Time Factors
Reg. No./Substance:
0/Biological Products; 108778-82-1/beractant

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