Document Detail

Surfactant abnormality and the sudden infant death syndrome--a primary or secondary phenomenon?
MedLine Citation:
PMID:  2386385     Owner:  NLM     Status:  MEDLINE    
A prospective study of 46 infant deaths occurring between 3 and 100 weeks of age was performed and comprised a structured necropsy followed by collection of lung washings for surfactant phospholipid analysis and samples for microbiological examination. Of the 46 infants studied, 23 died from sudden infant death syndrome (SIDS) alone; SIDS was the cause of death in a further 12 but there were additional clinical or pathological findings insufficient in themselves to account for the death ('SIDS-plus'). In 11 there were other causes of death ('non-SIDS'). The lung washings from infants dying from SIDS had significantly lower concentrations of phosphatidylcholine and a significantly lower palmitate content in the phosphatidylcholine. There was no association between surfactant phospholipid abnormality and the presence of recognised pathogens, histological evidence of pulmonary inflammation, aspiration of stomach contents, age at death, sex, and death-postmortem interval. There were, however, lower concentrations of phosphatidylcholine and phosphatidylcholine palmitate content in infants colonised by organisms with reported phospholipase A2 activity.
D James; P J Berry; P Fleming; M Hathaway
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of disease in childhood     Volume:  65     ISSN:  1468-2044     ISO Abbreviation:  Arch. Dis. Child.     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1990-09-14     Completed Date:  1990-09-14     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372434     Medline TA:  Arch Dis Child     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  774-8     Citation Subset:  AIM; IM    
Southmead Hospital, Bristol.
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MeSH Terms
Age Factors
Bronchoalveolar Lavage Fluid / analysis,  microbiology
Infant, Newborn
Inflammation / pathology
Phospholipases A / analysis
Phospholipases A2
Pneumonia, Aspiration / pathology
Prospective Studies
Pulmonary Surfactants / deficiency*
Respiratory System / pathology
Sudden Infant Death / etiology*,  pathology
Time Factors
Reg. No./Substance:
0/Pulmonary Surfactants; EC 3.1.1.-/Phospholipases A; EC A2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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