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Surfactant Replacement Therapy in Preterm Infants: A European Survey.
MedLine Citation:
PMID:  21228602     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: Exogenous surfactant is an undisputed treatment for neonatal respiratory distress syndrome but its efficacy is highly dependent on the treatment strategy. International guidelines have published recommendations on the optimal surfactant replacement strategy. Objective: To determine how evidence-based guidelines on surfactant replacement therapy are implemented in daily clinical practice. Methods: Data on surfactant replacement therapy, including preparation, dosing and timing, were collected in 173 European neonatal intensive care units (NICUs) by questionnaire and in a cohort of preterm infants mechanically ventilated on two separate predefined dates in these units. Results: All NICUs used animal-derived surfactant in the treatment of respiratory distress syndrome, with Poractant being most widely used (86%). The most frequently used first dose was 100 mg/kg (58%) and 200 mg/kg (39%) and all NICUs allowed for repeat dosing. 39% of the NICUs claimed to use prophylactic treatment (<15 min of life). Data on surfactant treatment were collected in 338 infants, with a median gestational age of 27 weeks and a birth weight of 860 g. All infants were treated with animal-derived surfactant. The median first dose was 168 mg/kg in the Poractant group compared with 100 mg/kg in the Beractant and Bovactant groups. Prophylactic treatment was used in 23% of the infants and 28% of the infants received surfactant >2 h after birth. 43% of the infants received multiple doses. Conclusions: With the exception of surfactant timing, guidelines on surfactant replacement therapy seem to be implemented in daily clinical practice in European NICUs.
Authors:
Anton H van Kaam; Anne P De Jaegere; Dorine Borensztajn; Peter C Rimensberger
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-11
Journal Detail:
Title:  Neonatology     Volume:  100     ISSN:  1661-7819     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-2-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101286577     Medline TA:  Neonatology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  71-77     Citation Subset:  -    
Copyright Information:
Copyright © 2011 S. Karger AG, Basel.
Affiliation:
Department of Neonatology, Emma Children's Hospital, Academic Medical Center, Amsterdam, The Netherlands.
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Investigator/Affiliation:
A Debeer / ; A Chemin / ; K Norbert / ; F Autret / ; A Andreou / ; A Kroon / ; A Minić / ; J Schwindt / ; H Brouwers / ; P van Reempts / ; H Hummler / ; M van Veenendaal / ; K Sarafidis / ; E Lopriore / ; F Mosca / ; T Schaible / ; A Jaarsma / ; V Polimeni / ; R Plavka / ; L Pazderova / ; J Patkai / ; G Moriette / ; A Valls I Soler / ; P Clarke / ; C Migliori / ; R Hentschel / ; J Sigalas / ; M Ehlen / ; C Fremerey / ; M Roujou-Gris / ; M Stamatin / ; Q Mok / ; S Ata / ; M Günther / ; J Kühr / ; U Seitz / ; M Vermeulen / ; R Knol / ; S Le Bouedec / ; D Szekessy / ; R Wauer / ; C Petropoulou / ; J Moreno Hernando / ; B Jonsson / ; T Mulder / ; D Sweet / ; E Herting / ; W Goepel / ; G Dimitriou / ; H Stuchlíková / ; M Baltogianni / ; S Andronikou / ; V Santillo / ; F Ferrero / ; I Arnault / ; J Dort / ; T Blanc / ; G Rocha / ; H Guimarães / ; D Virella / ; A Costa / ; S Pedro Frutuoso / ; J Biolek / ; S Stoicescu / ; M Schroth / ; C Cirstoveanu / ; W de Boode / ; S Medbo / ; I Müller-Hansen / ; C Poets / ; T Riedel / ; K Palmer / ; C Martano / ; I Stucin Gantar / ; P Biban / ; S Chatfield / ; J Ghesquiere / ; B Theret / ; S Samperiz / ; T Berger / ; V Rigo / ; A Balato / ; M Gresa Munoz / ; A Nunes / ; H Molendijk / ; S Beuger / ; A Puzas / ; S Hiedl / ; O Genzel-Boroviczeny / ; D Anhalt / ; J Möller / ; F Ingemansson / ; F Halbertsma / ; V de Cesaris / ; T Saarela / ; P Karagianni / ; C Tsakalidis / ; P Tølløfsrud / ; A Bougatef / ; R Sindelar / ; K Wisborg / ; T Brink Henriksen / ; C Flumini / ; V Carnielli / ; S Giannuzzo / ; A Dussart / ; D Brault / ; M Samy / ; A van Wien / ; M Cunha / ; E Paulino / ; H Schneider / ; A Sandvoss / ; P Dahlem / ; B Koester / ; E Olhanger / ; R Wentzell / ; C Ramos / ; M Augusta Areias / ; I Verber / ; G Presta / ; R Magaldi / ; R Agostino / ; O Lund / ; J Ulriksen / ; U Steder / ; D Faas / ; R Jensen / ; G Baroutis / ; V Gouder de Beauregard / ; G Zaharie / ; A Eng-Schwartz / ; M Heldmann / ; T Cezanne / ; A Pereira / ; M Nelle / ; F Uxa / ; M Norman / ; J Siegel / ; M Welsch / ; H Schiffmann / ; L Haftel / ; F Wild / ; P Bühr / ; B Simma / ; A Thirumurugan / ; S Mortensen / ; R Ciccotti / ; G Carli / ; D Milligan / ; H Gerleve / ; B Kumararatne / ; S Hakansson / ; D O'Donovan / ; F Reiterer / ; P Rimensberger / ; L Nietsch / ; B Nakstad / ; P Gancia / ; S Swanstrom / ; P Maton / ; E Cavatorta / ; R Tvarijonoviciene / ; M Hogan / ; P Zinn / ; M Freff / ; H Reigstad / ; G Olariu / ; G Gonşalves / ; M Escumalha / ; H Ornelas / ; A Serrano / ; S Anderssen / ; P Garcia / ; A Mendes Da Graşa / ; C Bender / ; M Wald / ; M Bohn / ; A Schnelke / ; T Trips / ; J Ladekjaer / ; F Thompson / ; E Lindberg / ; M Frigerio / ; F Pederzini / ; G De Nisi / ; G Saur / ; M Losa / ; A Toma / ; E Matu / ; S Eckhardt / ; M Bellettato / ; H Fahnenstich / ; P Hetzel / ; J Bland / ; B Oglaend / ; L Lehtonen / ; T Eichler / ; M Roth / ; A Meberg / ; T Kuehn / ; M Emeis /

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