| Surfactant protein-A inhibits mycoplasma-induced dendritic cell maturation through regulation of HMGB-1 cytokine activity. | |
| | |
MedLine Citation:
|
PMID: 20810986 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
During pulmonary infections, a careful balance between activation of protective host defense mechanisms and potentially injurious inflammatory processes must be maintained. Surfactant protein A (SP-A) is an immune modulator that increases pathogen uptake and clearance by phagocytes while minimizing lung inflammation by limiting dendritic cell (DC) and T cell activation. Recent publications have shown that SP-A binds to and is bacteriostatic for Mycoplasma pneumoniae in vitro. In vivo, SP-A aids in maintenance of airway homeostasis during M. pneumoniae pulmonary infection by preventing an overzealous proinflammatory response mediated by TNF-α. Although SP-A was shown to inhibit maturation of DCs in vitro, the consequence of DC/SP-A interactions in vivo has not been elucidated. In this article, we show that the absence of SP-A during M. pneumoniae infection leads to increased numbers of mature DCs in the lung and draining lymph nodes during the acute phase of infection and, consequently, increased numbers of activated T and B cells during the course of infection. The findings that glycyrrhizin, a specific inhibitor of extracellular high-mobility group box-1 (HMGB-1) abrogated this effect and that SP-A inhibits HMGB-1 release from immune cells suggest that SP-A inhibits M. pneumoniae-induced DC maturation by regulating HMGB-1 cytokine activity. |
| | |
Authors:
|
Julie G Ledford; Bernice Lo; Michele M Kislan; Joseph M Thomas; Katherine Evans; Derek W Cain; Monica Kraft; Kristi L Williams; Jo Rae Wright |
Related Documents
:
|
3076476 - Activation of macrophages by neuropeptides. 1381066 - Dorsal column stimulation induces release of serotonin and substance p in the cat dorsa... 12244146 - Pulmonary surfactant protein a up-regulates activity of the mannose receptor, a pattern... 15312716 - Interactive effects of temperature and copper on immunocompetence and disease susceptib... 12223446 - Anti-monocyte chemoattractant protein-1 gene therapy inhibits restenotic changes (neoin... 16914646 - Cytokine secretion profiles of human keratinocytes during trichophyton tonsurans and ar... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-09-01 |
Journal Detail:
|
Title: Journal of immunology (Baltimore, Md. : 1950) Volume: 185 ISSN: 1550-6606 ISO Abbreviation: J. Immunol. Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-09-22 Completed Date: 2010-10-19 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 2985117R Medline TA: J Immunol Country: United States |
Other Details:
|
Languages: eng Pagination: 3884-94 Citation Subset: AIM; IM |
Affiliation:
|
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blotting, Western Cell Differentiation / immunology Cell Separation Dendritic Cells / cytology, immunology*, metabolism Flow Cytometry HMGB1 Protein / immunology*, metabolism Mice Mice, Inbred C57BL Mice, Mutant Strains Mycoplasma Infections / immunology*, metabolism Mycoplasma pneumoniae / immunology Pulmonary Surfactant-Associated Protein A / immunology*, metabolism |
| Grant Support | |
ID/Acronym/Agency:
|
AI81672/AI/NIAID NIH HHS; F32HL091642/HL/NHLBI NIH HHS; HL084917/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/HMGB1 Protein; 0/Pulmonary Surfactant-Associated Protein A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Latent membrane protein 1, the EBV-encoded oncogenic mimic of CD40, accelerates autoimmunity in B6.S...
Next Document: T Cell-Induced Mast Cell Activation: A Role for Microparticles Released from Activated T Cells.