| Surfactant protein D-mediated decrease of allergen-induced inflammation is dependent upon CTLA4. | |
| | |
MedLine Citation:
|
PMID: 20435925 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Pulmonary surfactant protein D (SP-D), a member of the collectin family, is an innate immune molecule critical for defense that can also modulate adaptive immune responses. We previously showed that SP-D-deficient mice exhibit enhanced allergic responses and that SP-D induction requires lymphocytes. Thus, we postulated that SP-D may decrease adaptive allergic responses through interaction with T cells. In this study, we used two forms of SP-D, a dodecamer and a shorter fragment containing the trimeric neck and carbohydrate recognition domains (SP-D NCRD). Both forms decreased immune responses in vitro and in a murine model of pulmonary inflammation. SP-D NCRD increased transcription of CTLA4, a negative regulator of T cell activation, in T cells. SP-D NCRD no longer decreased lymphoproliferation and IL-2 cytokine production when CTLA4 signals were abrogated. Administration of SP-D NCRD in vivo no longer decreased allergen induced responses when CTLA4 was inhibited. Our results indicate that SP-D decreases allergen responses, an effect that may be mediated by increase of CTLA4 in T cells. |
| | |
Authors:
|
Ko-Wei Lin; Kai Yu Jen; Carlos Jose Suarez; Erika C Crouch; David L Perkins; Patricia W Finn |
Related Documents
:
|
17430175 - Therapeutical approaches of vasoactive intestinal peptide as a pleiotropic immunomodula... 10808055 - Vasoactive intestinal peptide (vip) inhibits tgf-beta1 production in murine macrophages. 12060565 - Combined sp-a-bleomycin effect on cytokines by thp-1 cells: impact of surfactant lipids... 11181965 - The pulmonary collectins and surfactant metabolism. 20607865 - Effects of axon degeneration on oligodendrocyte lineage cells: dorsal rhizotomy evokes ... 16690965 - Apoptotic cells promote macrophage survival by releasing the antiapoptotic mediator sph... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-04-30 |
Journal Detail:
|
Title: Journal of immunology (Baltimore, Md. : 1950) Volume: 184 ISSN: 1550-6606 ISO Abbreviation: J. Immunol. Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-05-20 Completed Date: 2010-06-14 Revised Date: 2012-02-01 |
Medline Journal Info:
|
Nlm Unique ID: 2985117R Medline TA: J Immunol Country: United States |
Other Details:
|
Languages: eng Pagination: 6343-9 Citation Subset: AIM; IM |
Affiliation:
|
Division of Pulmonary and Critical Medicine, University of California, San Diego, La Jolla, CA 92093, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Allergens
/
immunology Animals Antigens, CD / immunology* CTLA-4 Antigen Enzyme-Linked Immunosorbent Assay Immunoglobulin E / blood, immunology Inflammation / immunology* Lymphocyte Activation / immunology Mice Mice, Inbred BALB C Ovalbumin / immunology Pulmonary Surfactant-Associated Protein D / immunology* Respiratory Hypersensitivity / immunology* Reverse Transcriptase Polymerase Chain Reaction T-Lymphocytes / immunology* Transfection |
| Grant Support | |
ID/Acronym/Agency:
|
5R01HL081663-05/HL/NHLBI NIH HHS; R01 AI053878-08/AI/NIAID NIH HHS; R01 AI053878-10/AI/NIAID NIH HHS; R01 AI075317-02/AI/NIAID NIH HHS; R01 HL081663-01/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Allergens; 0/Antigens, CD; 0/CTLA-4 Antigen; 0/Ctla4 protein, mouse; 0/Pulmonary Surfactant-Associated Protein D; 37341-29-0/Immunoglobulin E; 9006-59-1/Ovalbumin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cutting Edge: Mechanical Forces Acting on T Cells Immobilized via the TCR Complex Can Trigger TCR Si...
Next Document: Monocyte trafficking to hepatic sites of bacterial infection is chemokine independent and directed b...