| Surface tailoring of poly(DL-lactic acid) by ligand-tethered amphiphilic polymer for promoting chondrocyte attachment and growth. | |
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MedLine Citation:
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PMID: 14738850 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The ligand-tethered poly(ethylene oxide-propylene oxide-ethylene oxide) (PEO-PPO-PEO) triblock copolymer was explored to engineer poly(DL-lactic acid) (PDL-LA) material to promote cell attachment and growth. The PEO-PPO-PEO was activated by methyl sulfonyl chloride and the amino acid, and peptide were attached. By blending the PDL-LA with the ligand-tethered PEO-PPO-PEO derivatives, the surface of modified PDL-LA film was investigated by ATR-FTIR, XPS and contact angle. The chondrocytes test on different PDL-LA films indicated that the PEO-PPO-PEO amino acid and RGD derivatives modified PDL-LA films could promote chondrocyte attachment and growth. This simple surface treatment method may have potentials for tissue engineering and other biomedical applications. |
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Authors:
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Jian Ji; Huiguang Zhu; Jiacong Shen |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biomaterials Volume: 25 ISSN: 0142-9612 ISO Abbreviation: Biomaterials Publication Date: 2004 May |
Date Detail:
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Created Date: 2004-01-23 Completed Date: 2004-09-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8100316 Medline TA: Biomaterials Country: England |
Other Details:
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Languages: eng Pagination: 1859-67 Citation Subset: IM |
Affiliation:
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Department of Polymer Science and Engineering, Zhejiang University, 310027, Hangzhou, China. jianji@mail.hz.zj.cn |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adsorption Animals Cell Adhesion / physiology Cell Culture Techniques / methods* Cell Division / physiology Cells, Cultured Chondrocytes / cytology*, physiology* Coated Materials, Biocompatible / chemistry Lactic Acid / chemistry* Ligands Materials Testing Oligopeptides / chemistry, metabolism* Polyethylene Glycols / chemistry* Polymers / chemistry* Propylene Glycols / chemistry* Protein Binding Rabbits Surface Properties Surface-Active Agents / chemistry Tissue Engineering / methods* |
| Chemical | |
Reg. No./Substance:
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0/Coated Materials, Biocompatible; 0/Ligands; 0/Oligopeptides; 0/PEO-PPO-PEO; 0/Polyethylene Glycols; 0/Polymers; 0/Propylene Glycols; 0/Surface-Active Agents; 26100-51-6/poly(lactic acid); 50-21-5/Lactic Acid; 99896-85-2/arginyl-glycyl-aspartic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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