Document Detail


Surface plasmon resonance shows a gender difference in circulating annexin A5 in human.
MedLine Citation:
PMID:  22483902     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The level of circulating anxA5 is correlated to various diseases such as acute myocardial infarction, trauma, thrombosis, inflammation and in some cancers. Our aim was to assess whether a direct approach using surface plasmon resonance (SPR) could be easily used to provide a rapid and cheap alternative to detect anxA5 in blood samples in human. Our results indicate that SPR permits to detect and quantify circulating anxA5 in serum with a minimum time of manipulation. Furthermore, we report here, for the first time, that the level of circulating anxA5 is significantly higher in male than in female (5.43 (±0.02) and 4.41 (±0.2)ng/ml, respectively). In conclusion, we found that SPR can be used to rapidly quantify anxA5 in patients and that a gender difference has to be taken into account to explain gender differences in the prevalence of some diseases.
Authors:
Pascal Trouvé; Mathieu Kerbiriou; Sophie le Hir; Nathalie Benz; Claude Férec
Publication Detail:
Type:  Journal Article     Date:  2012-02-13
Journal Detail:
Title:  Talanta     Volume:  93     ISSN:  1873-3573     ISO Abbreviation:  Talanta     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2984816R     Medline TA:  Talanta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  219-23     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Affiliation:
Inserm, UMR1078, Brest F-29218, France; Université de Brest, Faculté de Médecine et des sciences de la santé, Brest F-29200, France.
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